Summer B, Ständer S, Kapp F, Thomas P
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.
Hautarzt. 2016 May;67(5):380-4. doi: 10.1007/s00105-016-3791-5.
The lymphocyte transformation test is used to determine T‑cell sensitization, whereby its benefit has been controversially discussed in the past.
What role does the lymphocyte transformation test have in the detection of metal sensitization?
Based on the current literature and our own work, the state of knowledge regarding the lymphocyte transformation test is presented.
In several studies, it was found that the lymphocyte transformation test, especially concerning metals, has sufficient specificity and sensitivity. Various modified test protocols that were more recently developed are also presented in this article. The lymphocyte transformation test is an assay which must be evaluated by the operating laboratories.
To detect metal sensitization, the lymphocyte transformation test can be useful especially in situations in which exposure did not occur via the skin, but from inside the body (e. g. by metal implants).
淋巴细胞转化试验用于确定T细胞致敏作用，过去对其益处一直存在争议。
淋巴细胞转化试验在检测金属致敏中起什么作用？
基于当前文献和我们自己的研究工作，介绍了关于淋巴细胞转化试验的知识现状。
在多项研究中发现，淋巴细胞转化试验，尤其是针对金属的试验，具有足够的特异性和敏感性。本文还介绍了最近开发的各种改良试验方案。淋巴细胞转化试验是一种必须由操作实验室进行评估的检测方法。
为检测金属致敏，淋巴细胞转化试验可能特别有用，尤其是在暴露并非通过皮肤而是从体内发生的情况下（例如通过金属植入物）。
