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大麻素对多发性硬化症中痉挛和共济失调的影响。

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.

作者信息

Meinck H M, Schönle P W, Conrad B

机构信息

Department of Clinical Neurophysiology, University of Göttingen, Federal Republic of Germany.

出版信息

J Neurol. 1989 Feb;236(2):120-2. doi: 10.1007/BF00314410.

DOI:10.1007/BF00314410
PMID:2709054
Abstract

The chronic motor handicaps of a 30-year-old multiple sclerosis patient acutely improved while he smoked a marihuana cigarette. This effect was quantitatively assessed by means of clinical rating, electromyographic investigation of the leg flexor reflexes and electromagnetic recording of the hand action tremor. It is concluded that cannabinoids may have powerful beneficial effects on both spasticity and ataxia that warrant further evaluation.

摘要

一名30岁的多发性硬化症患者在吸食大麻香烟时,其慢性运动障碍症状急剧改善。通过临床评分、腿部屈肌反射的肌电图检查以及手部动作震颤的电磁记录对这一效果进行了定量评估。结论是,大麻素可能对痉挛和共济失调都有强大的有益作用,值得进一步评估。

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本文引用的文献

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Cannabis effect on spasticity in spinal cord injury.
Arch Phys Med Rehabil. 1982 Mar;63(3):116-8.
2
The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat.鞘内注射左南曲朵和去乙酰左南曲朵对大鼠的镇痛作用。
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Effects of delta 9-tetrahydrocannabinol on cat spinal motoneurons.9-四氢大麻酚对猫脊髓运动神经元的影响。
Brain Res. 1983 Dec 12;288(1-2):283-7. doi: 10.1016/0006-8993(83)90104-x.
脊髓星形胶质细胞大麻素受体控制病理性震颤。
Nat Neurosci. 2021 May;24(5):658-666. doi: 10.1038/s41593-021-00818-4. Epub 2021 Mar 18.
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Tremor in Multiple Sclerosis-An Overview and Future Perspectives.多发性硬化症中的震颤——综述与未来展望
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5
Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies.靶向内源性大麻素系统:一种针对脑部疾病管理的预测性、预防性和个性化医学指导方法。
EPMA J. 2020 Apr 15;11(2):217-250. doi: 10.1007/s13167-020-00203-4. eCollection 2020 Jun.
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Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome.大麻素、Δ-9-四氢大麻酚(THC)和大麻二酚(CBD)联合治疗通过改变肠道微生物群缓解实验性自身免疫性脑脊髓炎(EAE)。
Brain Behav Immun. 2019 Nov;82:25-35. doi: 10.1016/j.bbi.2019.07.028. Epub 2019 Jul 26.
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Upper Limb Intention Tremor in Multiple Sclerosis: An Evidence-Based Review of Assessment and Treatment.多发性硬化症中的上肢意向性震颤:评估与治疗的循证综述
Int J MS Care. 2018 Sep-Oct;20(5):211-223. doi: 10.7224/1537-2073.2017-024.
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Spotlight on postural control in patients with multiple sclerosis.聚焦多发性硬化症患者的姿势控制
Degener Neurol Neuromuscul Dis. 2018 Apr 3;8:25-34. doi: 10.2147/DNND.S135755. eCollection 2018.
9
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Clin Neuropharmacol. 2016 Nov/Dec;39(6):311-319. doi: 10.1097/WNF.0000000000000179.
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4
Tetrahydrocannabinol for tremor in multiple sclerosis.四氢大麻酚用于治疗多发性硬化症中的震颤。
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5
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6
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Neurosurgery. 1984 Dec;15(6):917-20.