Li Chen-Chen, Yang Shang-Dong
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Org Biomol Chem. 2016 May 11;14(19):4365-77. doi: 10.1039/c6ob00554c.
Various difunctionalizations of acrylamide can not only provide a simple approach to form a wide scope of functionalized oxindoles, but can also be applied and generated easily. This review concludes different difunctionalizations of acrylamide to synthesize oxindoles based on the mechanistic aspects. The goal is to encourage further mechanistic studies hopefully leading to an in-depth understanding of this strategy.
丙烯酰胺的各种双官能化反应不仅能提供一种简单的方法来形成种类广泛的官能化氧化吲哚，而且易于应用和生成。本综述基于机理方面总结了丙烯酰胺不同的双官能化反应以合成氧化吲哚。目的是鼓励进一步开展机理研究，有望促成对该策略的深入理解。
