Bond G G, McLaren E A, Lipps T E, Cook R R
Dow Chemical Company, Department of Epidemiology, Midland, MI 48674.
J Occup Med. 1989 Feb;31(2):121-3.
This study provided 2 additional years of follow-up through 1984 for a previously studied cohort of 2192 employees potentially exposed to chlorinated dioxins. A separate analysis was done of the subgroup of 323 workers who had chloracne. No clear evidence was found for a causal association between any cause of death and potential occupational exposures to the higher chlorinated phenols, derivative products, or the chlorinated dioxins. Particular focus was directed at mortality from cancers of the stomach, liver, connective and other soft tissue, nasal and nasopharynx, and the lymphomas. Analyses by various indices of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexa- to octachlorinated dioxins did not show deaths from these cancers to have been disproportionately distributed among the workers considered to have had the highest exposures.
本研究对之前研究的2192名可能接触过氯代二噁英的员工队列进行了跟踪，一直持续到1984年，又增加了两年的随访时间。对患有氯痤疮的323名工人亚组进行了单独分析。未发现任何死因与潜在职业接触高氯酚、衍生产品或氯代二噁英之间存在因果关联的明确证据。特别关注的是胃癌、肝癌、结缔组织和其他软组织癌、鼻和鼻咽癌以及淋巴瘤的死亡率。根据接触2,3,7,8 - 四氯二苯并 - p - 二噁英和六至八氯二噁英的各种指标进行的分析表明，这些癌症导致的死亡在被认为接触程度最高的工人中并未出现不成比例的分布。
