Shulman R J
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.
Am J Clin Nutr. 1989 May;49(5):879-83. doi: 10.1093/ajcn/49.5.879.
To determine the adequacy of zinc and copper supplementation for infants receiving total parenteral nutrition (TPN), we performed 24-h balance studies in infants with diarrhea and infants who had recently undergone surgery. Measurements were made at base line, 1, and 2 wk. Mean serum Zn and Cu levels of the diarrhea group remained normal and were low in the postoperative group but normalized over the study period. Mean 24-h Zn and Cu balances were positive in infants with diarrhea and negative in postoperative infants. The high Zn and Cu content in the gastrointestinal fluid loss associated with surgery may have accounted in part for this finding. Normal serum levels of Zn and Cu did not guarantee positive balance. No significant changes were found in serum albumin, alkaline phosphatase, or ceruloplasmin. The current Zn and Cu recommendations may be appropriate only for hospitalized infants who have no excessive gastrointestinal fluid losses.
为确定接受全胃肠外营养（TPN）的婴儿补充锌和铜是否充足，我们对腹泻婴儿和近期接受手术的婴儿进行了24小时平衡研究。在基线、1周和2周时进行测量。腹泻组的血清锌和铜平均水平保持正常，术后组较低，但在研究期间恢复正常。腹泻婴儿的24小时锌和铜平均平衡为正值，术后婴儿为负值。与手术相关的胃肠液丢失中锌和铜含量较高可能部分解释了这一发现。血清锌和铜水平正常并不能保证平衡为正值。血清白蛋白、碱性磷酸酶或铜蓝蛋白未发现显著变化。目前的锌和铜推荐量可能仅适用于没有过多胃肠液丢失的住院婴儿。
