Huang Yangle, Wang Rui, Pan Yunjian, Zhang Yang, Li Hang, Cheng Chao, Zheng Difan, Zheng Shanbo, Li Yuan, Shen Xuxia, Hu Haichuan, Cai Deng, Wang Shengfei, Zhang Yawei, Xiang Jiaqing, Sun Yihua, Zhang Jie, Chen Haiquan
Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
Oncotarget. 2016 Jun 14;7(24):35979-35988. doi: 10.18632/oncotarget.8745.
To evaluate the importance of specific driver mutations to the development and outcome of lung squamous cell cancer (SQCC) in never-smokers, we assessed the clinicopathological characteristics and outcomes of 597 patients who underwent complete resection of SQCCs. In total, 88 (14.7%) never-smokers and 509 (85.3%) ever-smokers were compared. The never-smokers included more females (42.05% vs. 1.57%, P < 0.001) and more often had a personal history of malignant disease (9.09% vs. 2.36%, P = 0.003). The tumors of never-smokers were more often poorly differentiated (70.45% vs. 53.24%, P = 0.010) and more often contained oncogenic mutations (21.05% vs 11.05%, P = 0.023), particularly EGFR mutations (13.16% vs 3.40%, P = 0.001). Never-smokers also tended to have poorer OS than smokers. Our results suggest lung SQCCs in never-smokers are a subtype distinct from SQCCs occurring in smokers.
为评估特定驱动基因突变对从不吸烟者肺鳞状细胞癌（SQCC）发生发展及预后的重要性，我们评估了597例行SQCC完整切除术患者的临床病理特征及预后。总共比较了88例（14.7%）从不吸烟者和509例（85.3%）曾经吸烟者。从不吸烟者中女性更多（42.05%对1.57%，P<0.001），且更常有恶性疾病个人史（9.09%对2.36%，P = 0.003）。从不吸烟者的肿瘤更常为低分化（70.45%对53.24%，P = 0.010），且更常含有致癌基因突变（21.05%对11.05%，P = 0.023），尤其是EGFR突变（13.16%对3.40%，P = 0.001）。从不吸烟者的总生存期也往往比吸烟者差。我们的结果表明，从不吸烟者的肺SQCC是一种与吸烟者中发生的SQCC不同的亚型。
