Durrieu J, Doussau A, Rieger A, Terrebonne E, Bouabdallah K, Zwolakowski M-D, Maget B, Dauba J, Mariette C, Trager S, Périé J-L, Robert B, Regueme S C, Bourdel-Marchasson I
Isabelle Bourdel-Marchasson, Département de gériatrie, Hôpital Xavier Arnozan, Centre Henri Choussat, Avenue du Haut-Lévêque, 33604 Pessac cedex, France. Phone: (+33) 557 65 65 71, Fax: (+33) 557 65 65 60, E-mail:
J Frailty Aging. 2012;1(3):138-43. doi: 10.14283/jfa.2012.22.
Cancer in older patient favours the development of frailty: feeling of exhaustion, loss of weight, decreased muscle strength, slow gait speed, and low physical activity.
To evaluate the efficacy of adapted physical activity phone advices in limiting the cancer-induced loss of autonomy and frailty phenotype development.
Multicenter randomized controlled trial.
Patients (>70y) undergoing curative treatment for cancer (n=400) will be recruited from 12 centres.
The intervention consists in phoned personalized physical activity advices related to strength, aerobic, balance, proprioception, and flexibility. The contacts are performed twice a month during six months and then monthly until 1 year. The intervention complements the PNNS booklet advices (National Nutritional Health Program). The trial compares «individualized phone advices + PNNS» to «usual care + PNNS».
Functional, cognitive, clinical and self-reported data are assessed before treatment and at 3, 6, 12, 18, and 24 month follow-up. The primary outcome is the proportion of subjects with a one-year decreased SPPB (Short Physical Performance Battery) score of one point or more, as compared to baseline. The secondary outcomes include quality of life items, rate of hospitalizations, institutionalizations, mortality, Fried phenotype at 1 and 2 years, and the SPPB score at 2 years.
This large trial will provide clinical data of the effects of an exercise advices intervention in older patients during cancer therapy on function and cognition evolution, and quality of life. The possibilities of minimizing the development of frailty phenotype due to these advices will be explored.
老年患者患癌症更容易出现身体虚弱：感到疲惫、体重减轻、肌肉力量下降、步态速度减慢以及身体活动量低。
评估通过电话提供适应性身体活动建议在限制癌症导致的自主能力丧失和虚弱表型发展方面的效果。
多中心随机对照试验。
将从12个中心招募接受癌症根治性治疗且年龄超过70岁的患者（n = 400）。
干预包括通过电话提供与力量、有氧、平衡、本体感觉和灵活性相关的个性化身体活动建议。在六个月内每月进行两次联系，之后每月一次直至1年。该干预是对法国国家营养健康计划（PNNS）手册建议的补充。试验将“个性化电话建议 + PNNS”与“常规护理 + PNNS”进行比较。
在治疗前以及随访的3、6、12、18和24个月时评估功能、认知、临床和自我报告数据。主要结局是与基线相比，SPPB（简短身体性能量表）得分在1年内下降1分或更多的受试者比例。次要结局包括生活质量项目、住院率、入住养老院率、死亡率、1年和2年时的弗里德虚弱表型以及2年时的SPPB得分。
这项大型试验将提供关于运动建议干预对老年癌症患者治疗期间功能和认知演变以及生活质量影响的临床数据。将探索通过这些建议使虚弱表型发展最小化的可能性。
