Lewis Anthony J, Billiar Timothy R, Rosengart Matthew R
Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.
Surg Infect (Larchmt). 2016 Jun;17(3):286-93. doi: 10.1089/sur.2015.262. Epub 2016 Apr 19.
Sepsis is a complex, heterogeneous physiologic condition that represents a significant public health concern. While many insights into the pathophysiology of sepsis have been elucidated over the past decades of research, important questions remain. This article serves as a review of several important areas in sepsis research. Understanding the innate immune response has been at the forefront as of late, especially in the context of cytokine-directed therapeutic trials. Cellular bioenergetic changes provide insight into the development of organ dysfunction in sepsis. Autophagy and mitophagy perform crucial cell housekeeping and stress response functions. Finally, age-related changes and their potential impact on the septic response are reviewed.
脓毒症是一种复杂的、异质性的生理状况，是一个重大的公共卫生问题。尽管在过去几十年的研究中已经阐明了许多关于脓毒症病理生理学的见解，但重要问题仍然存在。本文对脓毒症研究中的几个重要领域进行综述。近年来，对固有免疫反应的理解一直处于前沿，尤其是在细胞因子导向治疗试验的背景下。细胞生物能量学变化为脓毒症中器官功能障碍的发展提供了见解。自噬和线粒体自噬发挥着关键的细胞清理和应激反应功能。最后，本文综述了与年龄相关的变化及其对脓毒症反应的潜在影响。
