Krick E L, Little L, Patel R, Shofer F S, Sorenmo K, Clifford C A, Baez J L
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Vet Comp Oncol. 2008 Jun;6(2):102-10. doi: 10.1111/j.1476-5829.2007.00146.x.
Feline large granular lymphocyte (LGL) lymphoma is an uncommon, morphologically distinct variant of feline lymphoma. Limited information exists in the literature regarding pathological and immunohistochemical descriptions, clinical findings, treatment and survival times. The purpose of this study was to describe clinical features, treatment and outcome in feline LGL lymphoma. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. Decreased appetite/anorexia, weight loss, lethargy and vomiting were the most commonly reported clinical signs. All cats tested for feline leukaemia virus and feline immunodeficiency virus infection were negative. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis.
猫大颗粒淋巴细胞（LGL）淋巴瘤是猫淋巴瘤中一种罕见的、形态学上独特的变体。关于其病理和免疫组化描述、临床发现、治疗及生存时间，文献中的信息有限。本研究的目的是描述猫LGL淋巴瘤的临床特征、治疗及预后。对45只患有LGL淋巴瘤的猫的病历进行了回顾性评估。食欲减退/厌食、体重减轻、嗜睡和呕吐是最常报告的临床症状。所有检测猫白血病病毒和猫免疫缺陷病毒感染的猫均为阴性。肠系膜淋巴结和小肠是最常受累的器官。在23只接受化疗作为初始治疗的猫中，观察到1例完全缓解和6例部分缓解。接受治疗的猫的中位生存时间为57天。基于这些结果，猫LGL淋巴瘤似乎对化疗反应极小，且预后不良。
