Wu Haijiang, Deng Xinna, Shi Yonghong, Su Ye, Wei Jinying, Duan Huijun
Department of PathologyHebei Medical University, Shijiazhuang, China Key Laboratory of Kidney Diseases of Hebei ProvinceShijiazhuang, China.
Departments of Oncology & ImmunotherapyHebei General Hospital, Shijiazhuang, China.
J Endocrinol. 2016 Jun;229(3):R99-R115. doi: 10.1530/JOE-16-0021. Epub 2016 Apr 19.
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1α is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1α may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1α and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1α polymorphisms and T2DM are also discussed in this review.
2型糖尿病（T2DM）是一种以葡萄糖代谢紊乱为特征的慢性疾病。许多转录因子和共激活因子参与了这一过程。过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）是一种调节细胞能量代谢的重要转录共激活因子。越来越多的证据表明，PGC-1α参与了T2DM的调节。因此，更好地了解PGC-1α的作用可能有助于找到更有效的治疗策略。在此，我们综述了PGC-1α的最新研究进展，并讨论了其在肝脏、骨骼肌、胰腺和肾脏等主要葡萄糖代谢组织中的调控网络。本文还讨论了PGC-1α基因多态性与T2DM之间的显著关联。
