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维生素D缺乏患者补充维生素D的代谢效应(一项双盲临床试验)

Metabolic effects of vitamin D supplementation in vitamin D deficient patients (a double-blind clinical trial).

作者信息

Osati Saeed, Homayounfar Reza, Hajifaraji Majid

机构信息

National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Noncommunicable diseases research center, Fasa University of Medical Sciences, Fasa, Iran.

出版信息

Diabetes Metab Syndr. 2016 Apr-Jun;10(2 Suppl 1):S7-S10. doi: 10.1016/j.dsx.2016.01.007. Epub 2016 Jan 14.

Abstract

BACKGROUND

Vitamin D has recently been given a lot of attention for its role in controlling insulin secretion. Many studies have spoken of its role in weight management, blood sugar control and many other metabolic variables.

PATIENT AND METHODS

In a randomized double-blind clinical trial, 210 people with vitamin D deficiency were randomly allocated into two groups receiving vitamin D (50,000 units per week) or placebo for 8 weeks.

RESULTS

Vitamin D levels were significantly increased in the group receiving vitamin D supplementation (13.7±5.2 unit increase versus 0.8±2.8). The increased levels of vitamin D lead to significant changes in fasting insulin levels (6.8±8.1 unit reduction versus 2.3±3.7), a 2-h insulin (31.1±34.9 unit reduction versus 4.5±24.6) and Homeostasis Model Assessment (HOMA) indices.

CONCLUSION

Correction of vitamin D deficiency leads to increased insulin sensitivity that was significantly able to maintain glucose in the normal range with lower levels of insulin.

摘要

背景

维生素D在控制胰岛素分泌方面的作用最近备受关注。许多研究都提到了它在体重管理、血糖控制及许多其他代谢变量方面的作用。

患者与方法

在一项随机双盲临床试验中,210名维生素D缺乏者被随机分为两组,一组接受维生素D(每周50,000单位),另一组接受安慰剂,为期8周。

结果

接受维生素D补充剂的组中维生素D水平显著升高(增加13.7±5.2单位,而另一组增加0.8±2.8)。维生素D水平的升高导致空腹胰岛素水平(降低6.8±8.1单位,而另一组降低2.3±3.7)、2小时胰岛素水平(降低31.1±34.9单位,而另一组降低4.5±24.6)和稳态模型评估(HOMA)指数发生显著变化。

结论

纠正维生素D缺乏会导致胰岛素敏感性增加,显著能够以较低的胰岛素水平将血糖维持在正常范围内。

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