人体血浆和细胞外液中的抗氧化防御机制。

Antioxidant defenses in human blood plasma and extra-cellular fluids.

作者信息

Stocker Roland

机构信息

Vascular Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia.

出版信息

Arch Biochem Biophys. 2016 Apr 1;595:136-9. doi: 10.1016/j.abb.2015.11.021.

DOI:10.1016/j.abb.2015.11.021

PMID:27095230

Abstract

I had the fortune to be introduced to Helmut Sies during the mid 1980s, while working as a post-doctoral scientist at the University of California, Berkeley. At that time, Helmut was a frequent visitor of the Bruce Ames' laboratory and a leading authority in antioxidants and oxidative stress. His concepts, ideas and willingness to listen and make constructive suggestions have been far-reaching and visionary. Moreover, they have also been highly infectious, so much so that much of my research to this day has been on the same topic. The following is a personal recount on how the field of antioxidants has evolved since those exciting days in Berkeley.

摘要

20世纪80年代中期，我有幸结识了赫尔穆特·西尔斯，当时我是加利福尼亚大学伯克利分校的一名博士后科学家。那时，赫尔穆特是布鲁斯·艾姆斯实验室的常客，也是抗氧化剂和氧化应激领域的权威人士。他的概念、想法以及倾听他人并提出建设性建议的意愿影响深远且具有前瞻性。此外，它们还极具感染力，以至于直到今天我的许多研究都围绕着同一个主题展开。以下是我个人对自伯克利那些令人兴奋的日子以来抗氧化剂领域如何发展的叙述。