内源性心脏干细胞的发育起源与谱系可塑性
Developmental origin and lineage plasticity of endogenous cardiac stem cells.
作者信息
Santini Maria Paola, Forte Elvira, Harvey Richard P, Kovacic Jason C
机构信息
Cardiovascular Research Centre, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst 2010, Australia St Vincent's Clinical School, University of New South Wales, Kensington 2052, Australia Stem Cells Australia, Melbourne Brain Centre, The University of Melbourne, Parkville, Victoria 3010, Australia.
出版信息
Development. 2016 Apr 15;143(8):1242-58. doi: 10.1242/dev.111591.
Over the past two decades, several populations of cardiac stem cells have been described in the adult mammalian heart. For the most part, however, their lineage origins and in vivo functions remain largely unexplored. This Review summarizes what is known about different populations of embryonic and adult cardiac stem cells, including KIT(+), PDGFRα(+), ISL1(+)and SCA1(+)cells, side population cells, cardiospheres and epicardial cells. We discuss their developmental origins and defining characteristics, and consider their possible contribution to heart organogenesis and regeneration. We also summarize the origin and plasticity of cardiac fibroblasts and circulating endothelial progenitor cells, and consider what role these cells have in contributing to cardiac repair.
在过去二十年中，成年哺乳动物心脏中已发现了几类心脏干细胞群。然而，在很大程度上，它们的谱系起源和体内功能仍未得到充分探索。本综述总结了目前已知的胚胎和成年心脏干细胞的不同群体，包括KIT(+)、PDGFRα(+)、ISL1(+)和SCA1(+)细胞、侧群细胞、心脏球和心外膜细胞。我们讨论了它们的发育起源和定义特征，并考虑它们对心脏器官发生和再生的可能贡献。我们还总结了心脏成纤维细胞和循环内皮祖细胞的起源和可塑性，并探讨了这些细胞在心脏修复中的作用。
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