Ma Qilong, Liu Wengao, Jia Ran, Long Hao, Zhang Lanjun, Lin Peng, Zhao Hongyun, Ma Guowei
Sun Yat-sen University Cancer Center, Guangdong Esophageal Cancer Institute, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Oncotarget. 2016 Jun 21;7(25):38857-38863. doi: 10.18632/oncotarget.8754.
The association between esophageal cancer and prediagnosis alcohol consumption is well established. However, evidence that prediagnosis alcohol consumption affects postoperative survival in patients with lymph node-negative esophageal squamous cell carcinoma (ESCC) is lacking. We conducted a retrospective study on the effect of prediagnosis alcohol consumption on the postoperative survival of patients with lymph node-negative ESCC in China.
We enrolled 643 ESCC patients with negative lymphatic metastasis who had undergone esophagectomy between 1990 and 2005 at the Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China, and reviewed their demographic, pathologic, preoperative, and cancer outcome data obtained from medical records. These data were analyzed using life table and Kaplan-Meier analyses and multivariate Cox regression.
There was a significant reduction in 3- and 5-year survival in drinkers with lymph node-negative ESCC. For drinkers, 3- and 5-year survival rates were 43% and 36% respectively, whereas, for nondrinkers, the corresponding values were 63% and 58%, respectively (p < 0.05). Multivariate Cox regression showed that drinking (p = 0.001, relative risk =1.583) was an independent factor for survival in patients with lymph node-negative ESCC. Striated analysis revealed that drinking was an independent factor for survival in patients with stage II A (p = 0.008, relative risk =1.679), stage IB (p = 0.044, relative risk=1.517), and well (p=0.011, relative risk =1.783) and moderately (p = 0.002, relative risk = 1.915) differentiated ESCC.
Prediagnosis alcohol consumption is an independent prognostic factor for postoperative survival in patients with lymph node-negative ESCC.
食管癌与诊断前饮酒之间的关联已得到充分证实。然而，缺乏证据表明诊断前饮酒会影响淋巴结阴性食管鳞状细胞癌（ESCC）患者的术后生存。我们针对诊断前饮酒对中国淋巴结阴性ESCC患者术后生存的影响进行了一项回顾性研究。
我们纳入了643例1990年至2005年间在中国广州中山大学肿瘤防治中心胸外科接受食管切除术且淋巴结转移阴性的ESCC患者，并回顾了从病历中获取的人口统计学、病理学、术前及癌症转归数据。使用生命表、Kaplan-Meier分析和多变量Cox回归对这些数据进行分析。
淋巴结阴性ESCC饮酒者的3年和5年生存率显著降低。饮酒者的3年和5年生存率分别为43%和36%，而不饮酒者相应的生存率分别为63%和58%（p<0.05）。多变量Cox回归显示，饮酒（p = 0.001，相对风险=1.583）是淋巴结阴性ESCC患者生存的独立因素。分层分析显示，饮酒是II A期（p = 0.008，相对风险=1.679）、I B期（p = 0.044，相对风险=1.517）以及高分化（p = 0.011，相对风险 = 1.783）和中分化（p = 0.002，相对风险 = 1.915）ESCC患者生存的独立因素。
诊断前饮酒是淋巴结阴性ESCC患者术后生存的独立预后因素。
