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与富血小板纤维蛋白相比，β-磷酸三钙与胶原蛋白联合用于牙槽窝保存的临床影像学研究

Socket preservation by beta-tri-calcium phosphate with collagen compared to platelet-rich fibrin: A clinico-radiographic study.

作者信息

Das Swati, Jhingran Rajesh, Bains Vivek Kumar, Madan Rohit, Srivastava Ruchi, Rizvi Iram

机构信息

Department of Periodontology, Saraswati Dental College, Lucknow, Uttar Pradesh, India.

出版信息

Eur J Dent. 2016 Apr-Jun;10(2):264-276. doi: 10.4103/1305-7456.178298.

DOI:10.4103/1305-7456.178298
PMID:27095909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4813448/
Abstract

OBJECTIVES

This study was primarily designed to determine the clinico-radiographic efficacy of platelet-rich fibrin (PRF) and beta-tri-calcium phosphate with collagen (β-TCP-Cl) in preserving extraction sockets.

MATERIALS AND METHODS

For Group I (PRF), residual sockets (n = 15) were filled with autologous PRF obtained from patients' blood; and for Group II (β-TCP-Cl), residual sockets (n = 15) were filled with β-TCP-Cl. For the sockets randomly selected for Group II (β-TCP-Cl), the reshaped Resorbable Tissue Replacement cone was inserted into the socket.

RESULTS

Clinically, there was a significantly greater decrease in relative socket depth, but apposition in midcrestal height in Group II (β-TCP-Cl) as compared to Group I (PRF), whereas more decrease in buccolingual width of Group I (PRF) than Group II (β-TCP-Cl) after 6 months. Radiographically, the mean difference in socket height, residual ridge, and width (coronal, middle, and apical third of socket) after 6 months was higher in Group I (PRF) as compared to Group II (β-TCP-Cl). The mean density (in Hounsfield Units) at coronal, middle, and apical third of socket was higher in Group I (PRF) as compared to Group II (β-TCP-Cl). There were statistically significant apposition and resorption for Group I (PRF) whereas nonsignificant resorption and significant apposition for Group II (β-TCP-Cl) in buccal and lingual/palatal cortical plate, respectively, at 6 months on computerized tomography scan.

CONCLUSION

The use of either autologous PRF or β-TCP-Cl was effective in socket preservation. Results obtained from PRF were almost similar to β-TCP-Cl; therefore being autologous, nonimmune, cost-effective, easily procurable regenerative biomaterial, PRF proves to be an insight into the future biofuel for regeneration.

摘要

目的

本研究的主要目的是确定富血小板纤维蛋白（PRF）和含胶原蛋白的β-磷酸三钙（β-TCP-Cl）在保存拔牙窝方面的临床影像学疗效。

材料与方法

对于第一组（PRF），将从患者血液中获取的自体PRF填充到残余拔牙窝（n = 15）中；对于第二组（β-TCP-Cl），将β-TCP-Cl填充到残余拔牙窝（n = 15）中。对于随机选择进入第二组（β-TCP-Cl）的拔牙窝，将重塑的可吸收组织替代圆锥体插入拔牙窝。

结果

临床上，与第一组（PRF）相比，第二组（β-TCP-Cl）的相对拔牙窝深度显著降低，但牙槽嵴顶高度的骨增量更大，而6个月后第一组（PRF）的颊舌向宽度减小比第二组（β-TCP-Cl）更多。影像学上，6个月后第一组（PRF）在拔牙窝高度、剩余牙槽嵴和宽度（拔牙窝的冠方、中间和根尖三分之一）方面的平均差异高于第二组（β-TCP-Cl）。与第二组（β-TCP-Cl）相比，第一组（PRF）在拔牙窝冠方、中间和根尖三分之一处的平均密度（以亨氏单位计）更高。在计算机断层扫描中，6个月时第一组（PRF）在颊侧和舌侧/腭侧皮质板分别有统计学意义的骨增量和骨吸收，而第二组（β-TCP-Cl）有不显著的骨吸收和显著的骨增量。

结论

使用自体PRF或β-TCP-Cl进行拔牙窝保存均有效。PRF获得的结果与β-TCP-Cl几乎相似；因此，PRF作为自体、无免疫反应、经济高效且易于获取的再生生物材料，被证明是未来再生生物燃料的一个方向。

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2
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3
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4
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5
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9
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Front Endocrinol (Lausanne). 2023 May 17;14:1163696. doi: 10.3389/fendo.2023.1163696. eCollection 2023.
10
Research progress of platelet-rich fibrin in alveolar ridge preservation.富血小板纤维蛋白在牙槽嵴保存中的研究进展
Rev Assoc Med Bras (1992). 2022 Aug;68(8):1115-1119. doi: 10.1590/1806-9282.20211383.
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J Int Acad Periodontol. 2014 Jul;16(3):86-96.
4
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J Indian Soc Periodontol. 2014 May;18(3):346-51. doi: 10.4103/0972-124X.134573.
5
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6
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8
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10
Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans.自体富血小板纤维蛋白基质用于人体后拔牙窝愈合的定量评估
Int J Periodontics Restorative Dent. 2011 Jun;31(3):285-95.