Gowda Triveni Mavinakote, Jayashri Manjunath, Venkatesh Usha Govindaroy, Shah Rucha, Kumar Amanna Baron Tarun, Deepthi Manjunath, Priya Saloni
Department of Periodontics, Bapuji Dental College and Hospital, Davanagere, Karnataka, India.
Private Practitioner, Hiriyur, Karnataka, India.
J Indian Soc Periodontol. 2023 Nov-Dec;27(6):619-625. doi: 10.4103/jisp.jisp_43_23. Epub 2024 Jan 24.
To determine the clinico-radiographic efficiency of partially demineralized dentin matrix block (PDDM block), a mixture of PDDM with advanced-platelet-rich fibrin+ (A-PRF+) and injectable platelet-rich fibrin versus A-PRF+ alone in alveolar socket preservation.
Sixteen molar teeth indicated for extraction were randomly assigned into two groups. For the test group, sockets were packed with PDDM block and control group, with A-PRF+ plug alone. Clinical and radiographic cone-beam computed tomography methods were used to assess the horizontal and vertical ridge dimensional changes at baseline and 4 months.
Clinically, the mid buccal and palatal crestal height (10.25 ± 0.86 and 9.75 ± 0.28 mm) and alveolar ridge width (11.37 ± 0.25 mm) were significantly higher in the test group as compared to the control group, 4 months after tooth extraction ( < 0.01). Radiographically, there was improved apposition and nonsignificant resorption for the test group in ridge height and width, whereas statistically significant higher resorption was seen in the control group at 4 months.
The application of the PDDM block demonstrated efficacy in maintaining the dimensions of the extraction socket when compared to A-PRF+ alone. This autologous and immune-free regenerative biomaterial is widely obtainable, offering a glimpse into the potential of next-generation biofuels for regeneration.
确定部分脱矿牙本质基质块（PDDM块）、PDDM与富含高级血小板纤维蛋白+（A-PRF+）的混合物以及可注射富含血小板纤维蛋白在牙槽窝保存中相对于单独使用A-PRF+的临床影像学效果。
将16颗拟拔除的磨牙随机分为两组。试验组牙槽窝填充PDDM块，对照组仅填充A-PRF+栓。采用临床和锥形束计算机断层扫描方法评估基线和4个月时牙槽嵴水平和垂直尺寸的变化。
临床上，拔牙4个月后，试验组的颊侧和腭侧中央嵴高度（分别为10.25±0.86和9.75±0.28mm）以及牙槽嵴宽度（11.37±0.25mm）显著高于对照组（P<0.01）。影像学上，试验组牙槽嵴高度和宽度的骨附着改善且吸收不明显，而对照组在4个月时出现统计学上显著更高的吸收。
与单独使用A-PRF+相比，PDDM块的应用在维持拔牙窝尺寸方面显示出效果。这种自体且无免疫反应的再生生物材料易于获取，为下一代再生生物燃料的潜力提供了一定的参考。
