Holsback Luciane, Luppi Pedro Alex Ramsey, Silva Camile Sanches, Negrão Gustavo Kremer, Conde Gabriel, Gabriel Hugo Vinícius, Balestrieri João Vitor, Tomazella Lucas
Setor de Veterinária e Produção Animal, Universidade Estadual do Norte do Paraná - UENP, Bandeirantes, PR, Brasil.
Universidade Estadual do Norte do Paraná - UENP, Bandeirantes, PR, Brasil.
Rev Bras Parasitol Vet. 2016 Jul-Sep;25(3):353-8. doi: 10.1590/S1984-29612016025. Epub 2016 Apr 12.
The anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, used individually or in combination, was determined by the Fecal Egg Count Reduction (FECR) test and cultivation of larvae of anthelminthic-treated sheep grouped as follows: G1 (doramectin), G2 (fenbendazole), G3 (nitroxynil), G4 (doramectin + fenbendazole), G5 (doramectin + nitroxynil), G6 (fenbendazole + nitroxynil), G7 (doramectin + nitroxynil + fenbendazole), G8 (untreated). In addition to individually used doramectin and fenbendazole, the helminths were also resistant to the combination of doramectin + fenbendazole; nitroxynil + fenbendazole; and doramectin + nitroxynil + fenbendazole, with their FECR rates ranging from 62-83%. The helminths showed possible nitroxynil-resistance, but had low resistance when the drug was administered in combination with doramectin. The evaluation of individual helminth species revealed that fenbendazole was fully effective against Cooperia; doramectin (G1), moderately effective against Haemonchus and insufficiently active against Cooperia; nitroxynil, effective against Haemonchus and insufficiently active against Cooperia. It was concluded from the results that herd nematodes are resistant to doramectin, fenbendazole, and nitroxynil, and that the combined use of the drugs not only fails to significantly improve the anthelmintic efficiency against Haemonchus and Cooperia, but is also cost-ineffective.
通过粪便虫卵计数减少（FECR）试验以及对驱虫处理后的绵羊幼虫进行培养，确定了多拉菌素、芬苯达唑和硝碘酚腈单独使用或联合使用时的驱虫效果。将绵羊分为以下几组：G1（多拉菌素）、G2（芬苯达唑）、G3（硝碘酚腈）、G4（多拉菌素+芬苯达唑）、G5（多拉菌素+硝碘酚腈）、G6（芬苯达唑+硝碘酚腈）、G7（多拉菌素+硝碘酚腈+芬苯达唑）、G8（未处理）。除了单独使用的多拉菌素和芬苯达唑外，蠕虫对多拉菌素+芬苯达唑、硝碘酚腈+芬苯达唑以及多拉菌素+硝碘酚腈+芬苯达唑的组合也具有抗性，其FECR率在62%-83%之间。蠕虫表现出可能对硝碘酚腈有抗性，但当该药物与多拉菌素联合使用时抗性较低。对单个蠕虫种类的评估表明，芬苯达唑对库珀属线虫完全有效；多拉菌素（G1）对血矛线虫有中等效果，对库珀属线虫活性不足；硝碘酚腈对血矛线虫有效，对库珀属线虫活性不足。结果表明，群体线虫对多拉菌素、芬苯达唑和硝碘酚腈具有抗性，联合使用这些药物不仅不能显著提高对血矛线虫和库珀属线虫的驱虫效果，而且成本效益不高。
