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前列腺癌碳离子放疗中因摆位不确定性和射程不确定性导致束角改变时直肠剂量的变化

Changes in Rectal Dose Due to Alterations in Beam Angles for Setup Uncertainty and Range Uncertainty in Carbon-Ion Radiotherapy for Prostate Cancer.

作者信息

Kubota Yoshiki, Kawamura Hidemasa, Sakai Makoto, Tsumuraya Ryou, Tashiro Mutsumi, Yusa Ken, Kubo Nobuteru, Sato Hiro, Kawahara Masahiro, Katoh Hiroyuki, Kanai Tatsuaki, Ohno Tatsuya, Nakano Takashi

机构信息

Gunma University Heavy Ion Medical Center, Gunma, Japan.

出版信息

PLoS One. 2016 Apr 20;11(4):e0153894. doi: 10.1371/journal.pone.0153894. eCollection 2016.

DOI:10.1371/journal.pone.0153894
PMID:27097041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4838308/
Abstract

BACKGROUND AND PURPOSE

Carbon-ion radiotherapy of prostate cancer is challenging in patients with metal implants in one or both hips. Problems can be circumvented by using fields at oblique angles. To evaluate the influence of setup and range uncertainties accompanying oblique field angles, we calculated rectal dose changes with oblique orthogonal field angles, using a device with fixed fields at 0° and 90° and a rotating patient couch.

MATERIAL AND METHODS

Dose distributions were calculated at the standard angles of 0° and 90°, and then at 30° and 60°. Setup uncertainty was simulated with changes from -2 mm to +2 mm for fields in the anterior-posterior, left-right, and cranial-caudal directions, and dose changes from range uncertainty were calculated with a 1 mm water-equivalent path length added to the target isocenter in each angle. The dose distributions regarding the passive irradiation method were calculated using the K2 dose algorithm.

RESULTS

The rectal volumes with 0°, 30°, 60°, and 90° field angles at 95% of the prescription dose were 3.4±0.9 cm3, 2.8±1.1 cm3, 2.2±0.8 cm3, and 3.8±1.1 cm3, respectively. As compared with 90° fields, 30° and 60° fields had significant advantages regarding setup uncertainty and significant disadvantages regarding range uncertainty, but were not significantly different from the 90° field setup and range uncertainties.

CONCLUSIONS

The setup and range uncertainties calculated at 30° and 60° field angles were not associated with a significant change in rectal dose relative to those at 90°.

摘要

背景与目的

对于一侧或双侧髋关节有金属植入物的前列腺癌患者，碳离子放射治疗具有挑战性。使用倾斜角度的射野可规避相关问题。为评估伴随倾斜射野角度的摆位和射程不确定性的影响，我们使用具有0°和90°固定射野及旋转患者治疗床的设备，计算了倾斜正交射野角度下的直肠剂量变化。

材料与方法

在标准角度0°和90°计算剂量分布，然后在30°和60°计算。通过在前后、左右和头脚方向上使射野变化-2毫米至+2毫米来模拟摆位不确定性，并通过在每个角度向靶等中心添加1毫米水等效路径长度来计算射程不确定性导致的剂量变化。使用K2剂量算法计算被动照射方法的剂量分布。

结果

在处方剂量的95%时，0°、30°、60°和90°射野角度下的直肠体积分别为3.4±0.9立方厘米、2.8±1.1立方厘米、2.2±0.8立方厘米和3.8±1.1立方厘米。与90°射野相比，30°和60°射野在摆位不确定性方面具有显著优势，在射程不确定性方面具有显著劣势，但在摆位和射程不确定性方面与90°射野无显著差异。

结论

相对于90°射野，在30°和60°射野角度计算的摆位和射程不确定性与直肠剂量的显著变化无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/01d2544036e4/pone.0153894.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/256f652ff2f6/pone.0153894.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/58b3f72adcc3/pone.0153894.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/06514f97c109/pone.0153894.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/01f9d813fe94/pone.0153894.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/01d2544036e4/pone.0153894.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/256f652ff2f6/pone.0153894.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/58b3f72adcc3/pone.0153894.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/06514f97c109/pone.0153894.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/01f9d813fe94/pone.0153894.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/692e/4838308/01d2544036e4/pone.0153894.g005.jpg

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2
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Radiat Oncol. 2015 Feb 27;10:56. doi: 10.1186/s13014-015-0348-1.
3
Carbon Ion Radiotherapy at the Gunma University Heavy Ion Medical Center: New Facility Set-up.群马大学重离子医学中心的碳离子放射疗法：新设施的建立。
实现前列腺癌质子治疗中实时 PGS 范围监测。
Sci Rep. 2021 Jul 28;11(1):15331. doi: 10.1038/s41598-021-93612-y.
4
Impact of Inter-fractional Anatomical Changes on Dose Distributions in Passive Carbon-Ion Radiotherapy for Prostate Cancer: Comparison of Vertical and Horizontal Fields.分次间解剖学变化对前列腺癌被动碳离子放射治疗剂量分布的影响：垂直野与水平野的比较
Front Oncol. 2020 Jul 28;10:1264. doi: 10.3389/fonc.2020.01264. eCollection 2020.
5
MRI response of obturator internus muscle to carbon-ion dose in prostate cancer treatment.MRI 评估前列腺癌碳离子治疗中闭孔内肌的剂量反应。
J Radiat Res. 2019 May 1;60(3):335-341. doi: 10.1093/jrr/rry111.
6
Probabilistic dose distribution from interfractional motion in carbon ion radiation therapy for prostate cancer shows rectum sparing with moderate target coverage degradation.前列腺癌碳离子放射治疗中分次间运动的概率剂量分布显示直肠受量降低，同时靶区覆盖度中度下降。
PLoS One. 2018 Aug 31;13(8):e0203289. doi: 10.1371/journal.pone.0203289. eCollection 2018.
7
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Cancers (Basel). 2011 Oct 26;3(4):4046-60. doi: 10.3390/cancers3044046.
4
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5
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