Zhou Qi, Liu Shu-min
Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4346-50.
With the development of the quality of life, the morbidity of hyperuricemia is increasing year by year. At the same time, it appears that this disease attacks the young people currently. As the study of pathogenesis of hyperuricemia advanced, a series of uric acid transporters were found during this process. Meanwhile, the definition of transporterome was proposed. They were divided into three groups according to the functions: reabsorption proteins, excretion proteins and skeleton proteins. At moment, the drugs for hyperuricmia mainly include uric acid composition inhibitors and uric acid excretion promoters. Since the excretion of uric acid plays a leading role during the process of attack of hyperurecimia, it makes sense to explore Chinese medicines with clear mechanism targeting the transporterome. Therefore, this paper would focus on transporterome and summarize the mechanisms of Chinese medicines in treating hyperuricemia.
随着生活质量的提高，高尿酸血症的发病率逐年上升。与此同时，这种疾病目前似乎正在侵袭年轻人。随着高尿酸血症发病机制研究的进展，在此过程中发现了一系列尿酸转运蛋白。同时，提出了转运体组的定义。根据功能将它们分为三组：重吸收蛋白、排泄蛋白和骨架蛋白。目前，治疗高尿酸血症的药物主要包括尿酸合成抑制剂和尿酸排泄促进剂。由于尿酸排泄在高尿酸血症发作过程中起主导作用，探索针对转运体组机制明确的中药是有意义的。因此，本文将聚焦于转运体组，总结中药治疗高尿酸血症的机制。
