Wang Yu, Lin Zhi-Jian, Zhang Bing
School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jun;49(12):3160-3167. doi: 10.19540/j.cnki.cjcmm.20240226.501.
The abnormal production and/or excretion of uric acid can lead to a disorder in uric acid metabolism, resulting in hyperuricemia, uric acid nephropathy, gouty arthritis, and other diseases related to uric acid metabolism disorder. The clinical incidence of these diseases is increasing year after year, posing a significant threat to public health. In the past, hyperuricemia and gouty arthritis were often considered different diseases, with uric acid nephropathy being a complication of hyperuricemia. However, recent research has challenged this perspective, suggesting that hyperuricemia, uric acid nephropathy, and gouty arthritis are different stages of the same disease, with urate deposition as the common pathological feature. This article offered a comprehensive overview of the current understanding of hyperuricemia, uric acid nephropathy, and gouty arthritis in both traditional Chinese medicine(TCM) and western medicine. It delved into the most up-to-date insights into the involvement of urate deposition in the pathogenesis of uric acid metabolism disorders and highlighted the dominant role of TCM in the prevention and treatment of uric acid metabolism disorders, so as to provide a reference for effective intervention strategies and drug development in uric acid metabolism disorder-related diseases.
尿酸的异常生成和/或排泄可导致尿酸代谢紊乱，引发高尿酸血症、尿酸肾病、痛风性关节炎以及其他与尿酸代谢紊乱相关的疾病。这些疾病的临床发病率逐年上升，对公众健康构成重大威胁。过去，高尿酸血症和痛风性关节炎常被视为不同的疾病，尿酸肾病是高尿酸血症的并发症。然而，最近的研究对这一观点提出了挑战，表明高尿酸血症、尿酸肾病和痛风性关节炎是同一种疾病的不同阶段，尿酸盐沉积是共同的病理特征。本文全面概述了中医和西医对高尿酸血症、尿酸肾病和痛风性关节炎的当前认识。深入探讨了尿酸盐沉积在尿酸代谢紊乱发病机制中的最新见解，并强调了中医在尿酸代谢紊乱防治中的主导作用，以便为尿酸代谢紊乱相关疾病的有效干预策略和药物开发提供参考。
