Chu Meng-Zhen, Zhang Bing, Lin Zhi-Jian, Zhang Xiao-Meng, Wang Yu
School of Chinese Pharmacy, Beijing University of Chinese Medicine Beijing 100029, China.
Zhongguo Zhong Yao Za Zhi. 2019 Apr;44(7):1485-1490. doi: 10.19540/j.cnki.cjcmm.20181213.004.
Through literature review, it was found that there were many literature reports on the effect of single-herb traditional Chinese medicine for lowering uric acid in comparison with other single-herb traditional Chinese medicines. Then what is the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid? How do they play a role in lowering uric acid? In this study, traditional Chinese medicines for eliminating dampness in the 2015 Chinese Pharmacopoeia and the innovative textbook of Clinical Chinese Pharmacy for Chinese medicine colleges and universities in the new century were selected as the research objects, and articles about the effect of single-herb traditional Chinese medicines for eliminating dampness in the treatment of hyperuricemia were searched through CNKI, WanFang and VIP. Afterwards, Excel(2016) was used to establish a database, and Excel screening tool was used to extract the classification statistics of its uric acid lowering effect, pharmacodynamic sites, uric acid lowering pathway and mechanism, so as to clarify the relationship between single-herb traditional Chinese medicines for eliminating dampness and uric acid as well as their mechanism on lowering uric acid. The results showed that there were 16 kinds of traditional Chinese medicines with uric acid lowering effect, accounting for 23.88% of the 67 kinds of traditional Chinese medicines for eliminating dampness. Other medicines with the uric acid lowering effect included traditional Chinese medicine extracts and chemical components. The main ways of reducing uric acid included: inhibiting uric acid synthesis and promoting uric acid excretion; mechanism of action was mainly regulating the two key enzymes generated by uric acid and the ion transporters excreted by uric acid. Therefore, it can be seen that this kind of traditional Chinese medicines have a clear effect in reducing uric acid, providing new ideas for drug screening, prescription compatibility and target determination for the treatment of hyperuricemia as well as a theoretical basis for the clinical treatment and research of hyperuricemia.
通过文献回顾发现，与其他单味中药相比，有许多关于单味中药降尿酸作用的文献报道。那么，祛湿单味中药与尿酸之间有什么关系？它们是如何发挥降尿酸作用的？本研究选取2015年《中国药典》中的祛湿中药以及新世纪全国高等中医药院校创新教材《临床中药学》中的祛湿中药作为研究对象，通过中国知网、万方和维普检索关于单味祛湿中药治疗高尿酸血症作用的文章。之后，使用Excel（2016）建立数据库，并利用Excel筛选工具提取其降尿酸作用、药效部位、降尿酸途径及机制的分类统计信息，以阐明祛湿单味中药与尿酸之间的关系及其降尿酸机制。结果显示，有16种中药具有降尿酸作用，占67种祛湿中药的23.88%。其他具有降尿酸作用的药物包括中药提取物和化学成分。降尿酸的主要途径包括：抑制尿酸合成和促进尿酸排泄；作用机制主要是调节尿酸生成的两种关键酶以及尿酸排泄的离子转运体。因此，可以看出这类中药在降尿酸方面有明确作用，为高尿酸血症的药物筛选、方剂配伍及靶点确定提供了新思路，也为高尿酸血症的临床治疗和研究提供了理论依据。
