Cornea, Cataract and Refractive Services, Centre for Sight Hospital, New Delhi, India.
ELZA Institute, Dietikon/Zurich; Laboratory for Ocular Cell Biology, University of Zurich, Zurich, Switzerland; University of Southern California, Roski Eye Institute, Los Angeles, CA, USA; Department of Ophthalmology, University of Wenzhou, Wenzhou, China.
Indian J Ophthalmol. 2019 Jan;67(1):8-15. doi: 10.4103/ijo.IJO_1403_18.
Corneal cross-linking (CXL), introduced by Wollensak et al. in 2003, is a minimally invasive procedure to halt the progression of keratoconus. Conventional CXL is recommended in eyes with corneal thickness of at least 400 microns after de-epithelialization to prevent endothelial toxicity. However, most of the keratoconic corneas requiring CXL may not fulfill this preoperative inclusion criterion. Moderate-to-advanced cases are often found to have a pachymetry less than this threshold. There are various modifications to the conventional method to circumvent this issue of CXL thin corneas while avoiding the possible complications. This review is an update on the modifications of conventional CXL for thin corneas.
角膜交联术（CXL）由 Wollensak 等人于 2003 年引入，是一种用于阻止圆锥角膜进展的微创手术。在去上皮化后角膜厚度至少为 400 微米的情况下，建议进行常规 CXL，以防止内皮毒性。然而，大多数需要 CXL 的圆锥角膜可能无法满足这一术前纳入标准。中重度病例常发现角膜厚度低于此阈值。为了解决 CXL 薄角膜的问题，同时避免可能的并发症，对常规方法进行了各种改进。本综述是对薄角膜常规 CXL 改良方法的更新。
