Leon-Soriano Elena, Alfonso Carolina, Yebenes Laura, Garcia-Polo Julio, Lassaletta Luis, Gavilan Javier
Department of Otolaryngology, La Paz University Hospital, La Paz University Hospital Institute for Health Research (IdiPAZ), Madrid, Spain.
Department of Pathology, La Paz University Hospital, Madrid, Spain.
Am J Case Rep. 2016 Apr 21;17:268-73. doi: 10.12659/ajcr.897623.
Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare malignant head and neck cancer thought to originate from the olfactory epithelium. It typically invades contiguous structures at presentation. We report a very rare case of multifocal and ectopic ONB.
A 41-year-old man presented with left nasal obstruction and occasional left epistaxis associated with headache. Endoscopic examination of the nasal cavities and computed tomography suggested bilateral polypoid masses. Histopathological diagnosis after endoscopic resection established bilateral olfactory neuroblastoma of the ethmoid sinuses. The patient received postoperative radiotherapy. He remains free of disease 4 years after treatment.
To the best of our knowledge this is the second documented case of multifocal ectopic olfactory neuroblastoma. Clinicians should consider ONB in the differential diagnosis of bilateral synchronous nasal and paranasal masses to avoid delayed diagnosis. Endoscopic resection of ONB could be an option in selected cases.
嗅神经母细胞瘤（ONB），也称为嗅感觉神经母细胞瘤，是一种罕见的头颈部恶性肿瘤，被认为起源于嗅上皮。它通常在发病时侵犯相邻结构。我们报告一例非常罕见的多灶性和异位性ONB病例。
一名41岁男性因左侧鼻塞、偶尔左侧鼻出血伴头痛就诊。鼻腔内镜检查和计算机断层扫描提示双侧息肉样肿物。内镜切除术后的组织病理学诊断为双侧筛窦嗅神经母细胞瘤。患者接受了术后放疗。治疗4年后他仍无疾病复发。
据我们所知，这是第二例有文献记载的多灶性异位嗅神经母细胞瘤病例。临床医生在双侧同步鼻腔和鼻窦肿物的鉴别诊断中应考虑ONB，以避免漏诊。在某些病例中，内镜切除ONB可能是一种选择。
