Carraro Júlia Cristina Cardoso, Mansego Maria Luisa, Milagro Fermin Ignacio, Chaves Larissa Oliveira, Vidigal Fernanda Carvalho, Bressan Josefina, Martínez J Alfredo
a Department of Nutrition and Health , Universidade Federal De Viçosa , Viçosa , Minas Gerais , Brazil ;
b Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research , University of Navarra, CIBERobn, Fisiopatología De La Obesidad Y La Nutrición, Institute of Health Carlos III , Pamplona , Madrid , Spain ;
Biomarkers. 2016 Nov;21(7):625-32. doi: 10.3109/1354750X.2016.1171904. Epub 2016 Apr 21.
We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n = 40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.
在一项横断面研究（n = 40）中，我们分析了整体基因和炎症基因甲基化是否可作为代谢变化的早期预测指标及其与饮食的关联。较高的整体甲基化与肥胖、胰岛素抵抗及较低的饮食质量相关。白细胞介素-6（IL-6）、丝氨酸蛋白酶抑制剂1（SERPINE1）和C反应蛋白（CRP）基因的甲基化与肥胖特征及常量营养素摄入有关。SERPINE1高甲基化也与一些代谢改变有关。CRP甲基化比CRP血浆浓度更能预测胰岛素抵抗。整体基因和炎症基因启动子高甲基化可能是肥胖和代谢变化的良好早期生物标志物，且与饮食质量相关。
