DNA甲基化对心血管代谢危险因素的影响：一项系统评价和荟萃分析。
Effects of DNA methylation on cardiometabolic risk factors: a systematic review and meta-analysis.
作者信息
Barouti Zahra, Heidari-Beni Motahar, Shabanian-Boroujeni Anahita, Mohammadzadeh Morteza, Pahlevani Vida, Poursafa Parnian, Mohebpour Fatemeh, Kelishadi Roya
机构信息
Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Hezar Jerib St, Isfahan, Iran.
Department of Nutrition, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Arch Public Health. 2022 Jun 2;80(1):150. doi: 10.1186/s13690-022-00907-1.
BACKGROUND
Epigenetic changes, especially DNA methylation have a main role in regulating cardiometabolic disorders and their risk factors. This study provides a review of the current evidence on the association between methylation of some genes (LINE1, ABCG1, SREBF1, PHOSPHO1, ADRB3, and LEP) and cardiometabolic risk factors.
METHODS
A systematic literature search was conducted in electronic databases including Web of Science, PubMed, EMBASE, Google Scholar and Scopus up to end of 2020. All observational human studies (cross-sectional, case-control, and cohort) were included. Studies that assessed the effect of DNA methylation on cardiometabolic risk factors were selected.
RESULTS
Among 1398 articles, eight studies and twenty-one studies were included in the meta-analysis and the systematic review, respectively. Our study showed ABCG1 and LINE1 methylation were positively associated with blood pressure (Fisher's zr = 0.07 (0.06, 0.09), 95% CI: 0.05 to 0.08). Methylation in LINE1, ABCG1, SREBF1, PHOSPHO1 and ADRB3 had no significant association with HDL levels (Fisher's zr = - 0.05 (- 0.13, 0.03), 95% CI:-0.12 to 0.02). Positive association was existed between LINE1, ABCG1 and LEP methylation and LDL levels (Fisher's zr = 0.13 (0.04, 0.23), 95% CI: 0.03 to 0.23). Moreover, positive association was found between HbA1C and ABCG1 methylation (Fisher's zr = 0.11 (0.09, 0.13), 95% CI: 0.09 to 0.12). DNA methylation of LINE1, ABCG1 and SREBF1 genes had no significant association with glucose levels (Fisher's zr = 0.01 (- 0.12, 0.14), 95% CI:-0.12 to 0.14).
CONCLUSION
This meta-analysis showed that DNA methylation was associated with some cardiometabolic risk factors including LDL-C, HbA1C, and blood pressure.
REGISTRATION
Registration ID of the protocol on PROSPERO is CRD42020207677 .
背景
表观遗传变化，尤其是DNA甲基化在调节心脏代谢紊乱及其风险因素中起主要作用。本研究综述了目前关于某些基因（LINE1、ABCG1、SREBF1、PHOSPHO1、ADRB3和LEP）甲基化与心脏代谢风险因素之间关联的证据。
方法
截至2020年底，在包括Web of Science、PubMed、EMBASE、谷歌学术和Scopus在内的电子数据库中进行了系统的文献检索。纳入所有观察性人体研究（横断面研究、病例对照研究和队列研究）。选择评估DNA甲基化对心脏代谢风险因素影响的研究。
结果
在1398篇文章中，分别有8项研究和21项研究纳入了荟萃分析和系统评价。我们的研究表明，ABCG1和LINE1甲基化与血压呈正相关（Fisher's zr = 0.07(0.06, 0.09)，95%CI：0.05至0.08）。LINE1、ABCG1、SREBF1、PHOSPHO1和ADRB³的甲基化与高密度脂蛋白水平无显著关联（Fisher's zr = -0.05(-0.13, 0.03)，95%CI：-0.12至0.02）。LINE1、ABCG1和LEP甲基化与低密度脂蛋白水平呈正相关（Fisher's zr = 0.13(0.04, 0.23)，95%CI：0.03至0.23）。此外，糖化血红蛋白与ABCG1甲基化呈正相关（Fisher's zr = 0.11(0.09, 0.13)，95%CI：0.09至0.12）。LINE1、ABCG1和SREBF1基因的DNA甲基化与血糖水平无显著关联（Fisher's zr = 0.01(-0.12, 0.14)，95%CI：-0.12至0.14）。
结论
这项荟萃分析表明，DNA甲基化与一些心脏代谢风险因素有关，包括低密度脂蛋白胆固醇、糖化血红蛋白和血压。
注册情况
该方案在PROSPERO上注册的ID为CRD42020207677。
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