Chang Arunchai, Aswakul Pitulak, Prachayakul Varayu
Arunchai Chang, Varayu Prachayakul, Siriraj Gastrointestinal Endoscopy Center, Division of Gastroenterology, Department of Internal Medicine, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok 10700, Thailand.
World J Clin Cases. 2016 Apr 16;4(4):112-7. doi: 10.12998/wjcc.v4.i4.112.
One of the most common symptoms presenting in patients with chronic pancreatitis is pancreatic-type pain. Obstruction of the main pancreatic duct in chronic pancreatitis can be treated by a multitude of therapeutic approaches, ranging from pharmacologic, endoscopic and radiologic treatments to surgical interventions. When the conservative treatment approaches fail to resolve symptomatic cases, however, endoscopic retrograde pancreatography with pancreatic duct drainage is the preferred second approach, despite its well-recognized drawbacks. When the conventional transpapillary approach fails to achieve the necessary drainage, the patients may benefit from application of the less invasive endoscopic ultrasound (EUS)-guided pancreatic duct interventions. Here, we describe the case of a 42-year-old man who presented with severe abdominal pain that had lasted for 3 mo. Computed tomography scanning showed evidence of chronic obstructive pancreatitis with pancreatic duct stricture at genu. After conventional endoscopic retrograde pancreaticography failed to eliminate the symptoms, EUS-guided pancreaticogastrostomy (PGS) was applied using a fully covered, self-expandable, 10-mm diameter metallic stent. The treatment resolved the case and the patient experienced no adverse events. EUS-guided PGS with a regular biliary fully covered, self-expandable metallic stent effectively and safely treated pancreatic-type pain in chronic pancreatitis.
慢性胰腺炎患者最常见的症状之一是胰源性疼痛。慢性胰腺炎主胰管梗阻可通过多种治疗方法进行处理,从药物治疗、内镜治疗、放射治疗到手术干预。然而,当保守治疗方法无法解决有症状的病例时,尽管存在公认的缺点,胰管引流的内镜逆行胰胆管造影仍是首选的第二种方法。当传统的经乳头途径无法实现必要的引流时,患者可能会受益于应用侵入性较小的内镜超声(EUS)引导下的胰管干预。在此,我们描述了一名42岁男性的病例,他出现严重腹痛已持续3个月。计算机断层扫描显示有慢性阻塞性胰腺炎的证据,胰管在膝部狭窄。在传统的内镜逆行胰胆管造影未能消除症状后,使用直径10毫米的全覆膜、自膨胀金属支架进行了EUS引导下的胰胃吻合术(PGS)。该治疗解决了问题,患者未出现不良事件。使用常规胆道全覆膜、自膨胀金属支架进行EUS引导下的PGS可有效、安全地治疗慢性胰腺炎的胰源性疼痛。