Joborn C, Rastad J, Stålberg E, Akerström G, Ljunghall S
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Muscle Nerve. 1989 Feb;12(2):87-94. doi: 10.1002/mus.880120202.
The muscle contraction of the anterior tibial muscle was investigated by measurements of electrically stimulated and computer-analyzed muscle twitches in 18 unselected patients with primary hyperparathyroidism (HPT) and in 20 healthy control persons. The HPT patients had a lower muscle twitch tension (TT) at single stimulation, compared with the control group [76 +/- 24 N (SD) and 99 +/- 33 N respectively, P less than 0.05]. At high-frequency stimulation the difference in muscle force increased, and at 20 Hz stimulation the force in the HPT patients was 73% of that in the controls (P less than 0.01). There were no differences between the HPT patients and the control persons in neither contraction time nor half relaxation time at single muscle twitch nor in twitch potentiation after 20 and 90 seconds maximal voluntary contraction. The results indicate that patients with primary HPT have an impaired muscle function of probable importance for their symptoms of weakness and generalized fatigue.
通过对18例未经挑选的原发性甲状旁腺功能亢进症（HPT）患者和20名健康对照者进行电刺激测量和计算机分析肌肉抽搐，研究了胫前肌的肌肉收缩情况。与对照组相比，HPT患者单次刺激时的肌肉抽搐张力（TT）较低[分别为76±24N（标准差）和99±33N，P<0.05]。在高频刺激时，肌肉力量的差异增大，在20Hz刺激时，HPT患者的力量为对照组的73%（P<0.01）。HPT患者与对照者在单次肌肉抽搐时的收缩时间、半松弛时间以及在20秒和90秒最大自主收缩后的抽搐增强方面均无差异。结果表明，原发性HPT患者存在肌肉功能受损，这可能对其虚弱和全身疲劳症状具有重要意义。
