Han Guang-Ming, Meza Jane L, Soliman Ghada A, Islam K M Monirul, Watanabe-Galloway Shinobu
Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Nutr Res. 2016 May;36(5):402-7. doi: 10.1016/j.nutres.2016.01.003. Epub 2016 Jan 9.
Metabolic syndrome increases the risk of mortality. Increased oxidative stress and inflammation may play an important role in the high mortality of individuals with metabolic syndrome. Previous studies have suggested that lycopene intake might be related to the reduced oxidative stress and decreased inflammation. Using data from the National Health and Nutrition Examination Survey, we examined the hypothesis that lycopene is associated with mortality among individuals with metabolic syndrome. A total of 2499 participants 20 years and older with metabolic syndrome were divided into 3 groups based on their serum concentration of lycopene using the tertile rank method. The National Health and Nutrition Examination Survey from years 2001 to 2006 was linked to the mortality file for mortality follow-up data through December 31, 2011, to determine the mortality rate and hazard ratios (HR) for the 3 serum lycopene concentration groups. The mean survival time was significantly higher in the group with the highest serum lycopene concentration (120.6 months; 95% confidence interval [CI], 118.8-122.3) and the medium group (116.3 months; 95% CI, 115.2-117.4), compared with the group with lowest serum lycopene concentration (107.4 months; 95% CI, 106.5-108.3). After adjusting for possible confounding factors, participants in the highest (HR, 0.61; P = .0113) and in the second highest (HR, 0.67; P = .0497) serum lycopene concentration groups showed significantly lower HRs of mortality when compared with participants in the lower serum lycopene concentration. The data suggest that higher serum lycopene concentration has a significant association with the reduced risk of mortality among individuals with metabolic syndrome.
代谢综合征会增加死亡风险。氧化应激和炎症增加可能在代谢综合征患者的高死亡率中起重要作用。先前的研究表明，摄入番茄红素可能与氧化应激降低和炎症减轻有关。利用美国国家健康与营养检查调查的数据，我们检验了番茄红素与代谢综合征患者死亡率相关的假设。使用三分位数排序法，将总共2499名20岁及以上的代谢综合征参与者根据其血清番茄红素浓度分为3组。2001年至2006年的美国国家健康与营养检查调查与截至2011年12月31日的死亡率随访数据的死亡档案相关联，以确定3个血清番茄红素浓度组的死亡率和风险比（HR）。血清番茄红素浓度最高组（120.6个月；95%置信区间[CI]，118.8 - 122.3）和中等组（116.3个月；95%CI，115.2 - 117.4）的平均生存时间显著高于血清番茄红素浓度最低组（107.4个月；95%CI，106.5 - 108.3）。在调整可能的混杂因素后，血清番茄红素浓度最高组（HR，0.61；P = 0.0113）和第二高组（HR，0.67；P = 0.0497）的参与者与血清番茄红素浓度较低组的参与者相比，死亡率的HR显著降低。数据表明，较高的血清番茄红素浓度与代谢综合征患者死亡风险降低显著相关。
