Takayanagi Yuji, Obana Akira, Muto Shigeki, Asaoka Ryo, Tanito Masaki, Ermakov Igor V, Bernstein Paul S, Gellermann Werner
Department of Ophthalmology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, Japan.
Antioxidants (Basel). 2021 Dec 22;11(1):14. doi: 10.3390/antiox11010014.
Carotenoids have potential antioxidant and anti-inflammatory effects; their protective roles are of particular interest in the pathogenesis of metabolic syndrome (MetS). The reflection spectroscopy method has been recently developed to noninvasively measure skin carotenoid (SC) levels, which highly correlates with serum concentration of carotenoids. The relationship between SC levels and metabolic syndrome has been investigated. We aimed to identify the differences in patient characteristics and SC levels between participants with and without MetS in a large health examination population. In addition, the relationships between SC levels and various clinical parameters related to MetS were investigated. SC levels were measured using a reflection spectroscopy. A total of 1812 Japanese participants (859 male, 953 female; mean age ± standard deviation (SD), 57.8 ± 11.0 years) comprised the study population, i.e., participants with MetS ( = 151) and those without MetS ( = 1661). Multivariate logistic regression analysis was performed to identify variables associated with MetS. Compared to controls (377.3 ± 122.8), SC indices were significantly lower in patients with MetS (340.7 ± 112.5, = 0.0004). Multivariate models also suggested that lower SC was significantly associated with MetS after adjustment for age, sex, smoking habit, and other potential risk factors for MetS. Furthermore, male gender ( < 0.0001), smoking habit ( < 0.0001) and worse lipid profiles (i.e., serum triglyceride ( = -0.1039, < 0.0001), high-density lipoprotein ( = 0.1259, < 0.0001), and usage of hypolipidemic agents ( = 0.0340)) were significantly associated with lower SC levels. The current study indicated that lower SC levels were significantly associated with MetS. This study highlights the antioxidant capacity of carotenoids in patients with MetS and the clinical utility of non-invasive and cost-effective SC measurement to detect participants who are at risk of developing MetS in a large population.
类胡萝卜素具有潜在的抗氧化和抗炎作用；它们的保护作用在代谢综合征（MetS）的发病机制中尤为令人关注。反射光谱法最近已被开发用于无创测量皮肤类胡萝卜素（SC）水平，其与血清类胡萝卜素浓度高度相关。人们已经对SC水平与代谢综合征之间的关系进行了研究。我们旨在确定在一个大型健康体检人群中，患有和未患有MetS的参与者在患者特征和SC水平上的差异。此外，还研究了SC水平与各种与MetS相关的临床参数之间的关系。使用反射光谱法测量SC水平。共有1812名日本参与者（859名男性，953名女性；平均年龄±标准差（SD），57.8±11.0岁）组成了研究人群，即患有MetS的参与者（=151）和未患有MetS的参与者（=1661）。进行多因素逻辑回归分析以确定与MetS相关的变量。与对照组（377.3±122.8）相比，患有MetS的患者的SC指数显著较低（340.7±112.5，=0.0004）。多因素模型还表明，在调整年龄、性别、吸烟习惯和其他MetS潜在风险因素后，较低的SC与MetS显著相关。此外，男性（<0.0001）、吸烟习惯（<0.0001）和较差的血脂谱（即血清甘油三酯（=-0.1039，<0.0001）、高密度脂蛋白（=0.1259，<0.0001）以及使用降脂药物（=0.0340））与较低的SC水平显著相关。当前研究表明，较低的SC水平与MetS显著相关。本研究强调了类胡萝卜素在MetS患者中的抗氧化能力以及无创且经济有效的SC测量在检测大量人群中处于发生MetS风险的参与者方面的临床实用性。
