补充胆钙化醇对动脉僵硬度的影响：一项系统评价和荟萃分析。
Effect of cholecalciferol supplementation on arterial stiffness: a systematic review and meta-analysis.
作者信息
Upala Sikarin, Sanguankeo Anawin, Congrete Soontharee, Jaruvongvanich Veeravich
机构信息
a Department of Internal Medicine , Bassett Medical Center and Columbia University College of Physicians and Surgeons , Cooperstown , NY , USA ;
b Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital , Mahidol University , Bangkok , Thailand ;
出版信息
Scand Cardiovasc J. 2016 Aug;50(4):230-5. doi: 10.3109/14017431.2016.1173226. Epub 2016 May 18.
BACKGROUND
Vitamin D deficiency increases risk of cardiovascular diseases, arterial stiffness, and endothelial dysfunction. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the impact of vitamin D supplementation on arterial stiffness.
METHODS
A comprehensive search of the databases of the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE was performed from inception through November 2015. The inclusion criterion was RCTs that assessed the impact of cholecalciferol supplementation in adults on the surrogate markers of arterial stiffness (aortic pulse wave velocity (PWV) and augmentation index (AIx)). Outcome was the pooled mean difference (MD) of PWV and AIx between the vitamin D supplementation (intervention) group and placebo.
RESULTS
The initial search yielded 1164 articles. Twenty-eight articles underwent full-length review and data were extracted from seven RCTs involving totally 547 participants. Dose of cholecalciferol supplementation varied from 1000 IU/day to 120,000 IU/month of cholecalciferol. Duration of treatment ranged from 2 to 12 months. There was no significant difference in the change of PWV (pooled MD = 0.18, 95% CI: -0.17 to 0.52 or AIx (pooled MD = 2.39, 95% CI: -4.43 to 4.92) between the intervention group and placebo.
CONCLUSIONS
There was no improvement of markers of arterial stiffness after vitamin D supplementation.
背景
维生素D缺乏会增加心血管疾病、动脉僵硬度和内皮功能障碍的风险。我们对随机对照试验（RCT）进行了系统评价和荟萃分析，以研究补充维生素D对动脉僵硬度的影响。
方法
从创刊至2015年11月，对Cochrane对照试验中央注册库、MEDLINE和EMBASE数据库进行了全面检索。纳入标准为评估补充胆钙化醇对成人动脉僵硬度替代指标（主动脉脉搏波速度（PWV）和增强指数（AIx））影响的随机对照试验。结果是维生素D补充（干预）组和安慰剂组之间PWV和AIx的合并平均差（MD）。
结果
初步检索得到1164篇文章。28篇文章进行了全文审查，并从7项随机对照试验中提取了数据，共涉及547名参与者。胆钙化醇补充剂量从1000 IU/天到120,000 IU/月不等。治疗持续时间为2至12个月。干预组和安慰剂组之间PWV（合并MD = 0.18，95%CI：-0.17至0.52）或AIx（合并MD = 2.39，95%CI：-4.43至4.92）的变化无显著差异。
结论
补充维生素D后动脉僵硬度指标无改善。
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