School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
Alzheimers Dement. 2016 Sep;12(9):931-941. doi: 10.1016/j.jalz.2016.03.003. Epub 2016 Apr 18.
We assessed the association of gamma glutamyltransferase (GGT) with risk of dementia.
Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort of 2415 relatively healthy men with good cognitive function. Correction was made for within-person variability in GGT levels.
During an average follow-up of 22 years, 219 new cases of dementia were recorded. Serum GGT was log-linearly associated with risk of dementia. The hazard ratio (HR) (95% CIs) for dementia per 1 standard deviation (SD) higher baseline loge GGT values was 1.33 (95% CI = 1.14-1.55) after adjustment for several established and emerging risk factors. The corresponding HR was 1.52 (95% CI = 1.22-1.89) after correction for within-person variability.
GGT is positively, log-linearly, and independently associated with future risk of dementia in the general male population. Further research is needed to unravel the mechanistic pathways of GGT in the pathogenesis of dementia.
我们评估了γ-谷氨酰转移酶（GGT）与痴呆风险的相关性。
在 Kuopio 缺血性心脏病前瞻性队列中，对 2415 名认知功能良好的相对健康男性进行了基线血清 GGT 活性评估。对 GGT 水平的个体内变异性进行了校正。
在平均 22 年的随访期间，记录到 219 例新的痴呆病例。血清 GGT 与痴呆风险呈对数线性相关。在调整了几个已确立和新兴的风险因素后，每增加 1 个标准差（SD）基线对数 GGT 值，痴呆的风险比（HR）（95%置信区间）为 1.33（95%CI=1.14-1.55）。在对个体内变异性进行校正后，相应的 HR 为 1.52（95%CI=1.22-1.89）。
GGT 与一般男性人群未来的痴呆风险呈正相关、对数线性相关且独立相关。需要进一步研究以阐明 GGT 在痴呆发病机制中的机制途径。
