Suzuki Chieko, Kon Tomoya, Funamizu Yukihisa, Ueno Tatsuya, Haga Rie, Nishijima Haruo, Arai Akira, Tomiyama Masahiko, Baba Masayuki
Department of Neurology, Aomori Prefectual Central Hospital, 2-1-1, Higashi-Tsukurimichi, Aomori, 030-8553, Japan.
Muscle Nerve. 2016 Jun;54(1):146-9. doi: 10.1002/mus.25158.
The loss of epidermal nerve fibers is regarded as an early pathological change in human diabetes. We investigated epidermal Aδ nerve fiber function by examining pain threshold by means of intraepidermal electrical stimulation (IES) in early diabetic neuropathy.
We recruited 20 asymptomatic diabetic patients. Eighteen age-matched, healthy subjects served as controls. We placed the IES electrode onto the skin of the foot dorsum and delivered weak electrical stimulation. We defined pain threshold as the minimum electrical intensity at which a subject felt a pricking sensation.
The mean pain thresholds in the patient group were significantly higher (0.053 ± 0.036 mA; P < 0.01) than in the control group (0.027 ± 0.006 mA).
We confirmed that the pain threshold was elevated in early diabetic neuropathy. We conclude that the IES electrode is a useful tool to evaluate early diabetic polyneuropathy. Muscle Nerve 54: 146-149, 2016.
表皮神经纤维的丧失被视为人类糖尿病的早期病理变化。我们通过在早期糖尿病神经病变中采用表皮内电刺激（IES）检测疼痛阈值来研究表皮Aδ神经纤维功能。
我们招募了20名无症状糖尿病患者。18名年龄匹配的健康受试者作为对照。我们将IES电极置于足背皮肤并给予弱电刺激。我们将疼痛阈值定义为受试者感到刺痛的最小电强度。
患者组的平均疼痛阈值（0.053±0.036 mA；P<0.01）显著高于对照组（0.027±0.006 mA）。
我们证实早期糖尿病神经病变中疼痛阈值升高。我们得出结论，IES电极是评估早期糖尿病多发性神经病变的有用工具。《肌肉与神经》54: 146 - 149, 2016年。
