Liu Mei, Song Jiayi, Jiang Yousheng, Liu Yuan, Peng Jinling, Liang Huiwen, Wang Chao, Jiang Jie, Liu Xinjie, Wei Wei, Peng Ji, Liu Si, Li Yingming, Xu Nan, Zhou Dongxian, Zhang Qinghua, Zhang Jianqing
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111615. doi: 10.1016/j.ecoenv.2020.111615. Epub 2020 Nov 12.
Thyroid tumor and thyroid goiter are prevalent disease around the world. In this case-control study, we investigated the association between exposure to a total of twelve mineral elements and thyroid disease as well as thyroid functions. Participants with thyroid tumor or goiter (N = 197) were matched with a healthy population (N = 197) by age (± 2 years old) and same sex. Questionnaires were used to collect data about the demographic characteristics and information of subjects. Serum and urine samples were collected simultaneously for each of the subjects. Mineral elements, iodine level of urine and levels of the total seven thyroid function indexes in serum were detected respectively. Conditional logistic regression was applied to estimate the associations between mineral elements and the risk of thyroid tumor and goiter through single-element models and multiple-element models. Multiple linear regression was used to evaluate relationships between mineral elements and percentage changes of thyroid functions. Higher concentrations of mineral elements in the recruited population were found in this study than other comparable studies, and the levels of chromium (Cr), manganese (Mn), nickel (Ni), arsenic (As), cadmium (Cd), selenium (Se), antimony (Sb), thallium (Tl) and lead (Pb) in the case group were lower than the control group. According to the single-element models, Cr, Mn, Ni, Sb and Tl showed significant negative associations with the risk of thyroid tumor and goiter, and, Cd showed nonmonotonic dose response. Cd and mercury (Hg) showed a nonmonotonic percentage change with T4, while Tl was associated with the increased FT4 in the control group. Therefore, Cd, Hg and Tl may disturb the balance of thyroid function to some extent, and Cr, Mn, Ni, Cd, Sb, and Tl may become potential influencing factors for the risk of thyroid tumor and goiter.
甲状腺肿瘤和甲状腺肿是全球范围内的常见疾病。在这项病例对照研究中，我们调查了总共12种矿物质元素的暴露与甲状腺疾病以及甲状腺功能之间的关联。患有甲状腺肿瘤或甲状腺肿的参与者（N = 197）与健康人群（N = 197）按年龄（±2岁）和性别进行匹配。通过问卷调查收集受试者的人口统计学特征和信息。同时为每个受试者采集血清和尿液样本。分别检测矿物质元素、尿碘水平和血清中总共七种甲状腺功能指标的水平。应用条件逻辑回归通过单元素模型和多元素模型估计矿物质元素与甲状腺肿瘤和甲状腺肿风险之间的关联。使用多元线性回归评估矿物质元素与甲状腺功能百分比变化之间的关系。本研究发现所招募人群中的矿物质元素浓度高于其他可比研究，病例组中的铬（Cr）、锰（Mn）、镍（Ni）、砷（As）、镉（Cd）、硒（Se）、锑（Sb）、铊（Tl）和铅（Pb）水平低于对照组。根据单元素模型，Cr、Mn、Ni、Sb和Tl与甲状腺肿瘤和甲状腺肿风险呈显著负相关，且Cd呈现非单调剂量反应。Cd和汞（Hg）与T4呈现非单调百分比变化，而Tl与对照组中FT4升高相关。因此，Cd、Hg和Tl可能在一定程度上扰乱甲状腺功能平衡，而Cr、Mn、Ni、Cd、Sb和Tl可能成为甲状腺肿瘤和甲状腺肿风险的潜在影响因素。
