Peters R K, Bear M B, Thomas D
Department of Preventive Medicine, University of Southern California School of Medicine, Los Angeles 90033.
Prev Med. 1989 Jan;18(1):133-46. doi: 10.1016/0091-7435(89)90059-5.
Despite the widespread availability and demonstrated efficacy of screening with the Papanicolaou smear, many women are screened irregularly or not at all. This study was designed to identify the barriers that prevent those women at risk for cervical cancer from being screened. Complete cervical cytology screening histories were taken during a population-based case-control study of invasive squamous cell carcinoma of the cervix involving 200 patients and their matched neighborhood controls. Smears taken during the previous 5 years were verified whenever possible. Ordinal logistic regression analysis was used to identify seven factors that significantly (P less than 0.05) and independently predicted regular recent screening among both cases and controls [failure to understand the importance and screening nature of cervical smears (-), expressed fears of embarrassment (-), having had a urogenital infection (+), number of pregnancies during the last 5 years (+), the number of pregnancies for which no prenatal care was sought (-), and knowledge of the recommended screening interval (+)], two variables that predicted screening among cases but not controls [age (-) and number of years of oral contraceptives use (+)], and one that predicted screening only among controls [years of living in the United States (+)]. Education, income, Latin heritage, being married, having a regular physician for one's medical care, and all other methods of birth control were significant predictors of screening in the univariate analyses, but were explained by the other more powerful predictors in the multivariate analysis.
尽管巴氏涂片筛查广泛可得且已证实其有效性,但许多女性接受筛查的情况并不规律,甚至完全不进行筛查。本研究旨在确定阻碍那些有患宫颈癌风险的女性进行筛查的障碍因素。在一项基于人群的宫颈癌浸润性鳞状细胞癌病例对照研究中,收集了200例患者及其匹配的社区对照的完整宫颈细胞学筛查史。尽可能核实过去5年所做的涂片。采用有序逻辑回归分析来确定七个因素,这些因素在病例组和对照组中均能显著(P值小于0.05)且独立地预测近期的定期筛查情况[不理解宫颈涂片的重要性和筛查性质(-)、表示担心尴尬(-)、有泌尿生殖系统感染(+)、过去5年的怀孕次数(+)、未寻求产前护理的怀孕次数(-)以及知晓推荐的筛查间隔时间(+)],两个变量在病例组中能预测筛查情况但在对照组中不能[年龄(-)和口服避孕药使用年限(+)],还有一个变量仅在对照组中能预测筛查情况[在美国居住的年限(+)]。在单因素分析中,教育程度、收入、拉丁裔血统、婚姻状况、有固定的医生提供医疗服务以及所有其他避孕方法都是筛查的显著预测因素,但在多因素分析中,这些因素可由其他更具影响力的预测因素来解释。