Wu Yi Xi, Kwon Young Jik
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, United States.
Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, United States; Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, United States; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, United States; Department of Biomedical Engineering, University of California, Irvine, CA 92697, United States.
Methods. 2016 Aug 15;106:21-8. doi: 10.1016/j.ymeth.2016.04.020. Epub 2016 Apr 19.
It has been more than two decades since the first aptamer molecule was discovered. Since then, aptamer molecules have gain much attention in the scientific field. This increasing traction can be attributed to their many desirable traits, such as 1) their potentials to bind a wide range of molecules, 2) their malleability, and 3) their low cost of production. These traits have made aptamer molecules an ideal platform to pursue in the realm of pharmaceuticals and bio-sensors. Despite the broad applications of aptamers, tedious procedure, high resource consumption, and limited nucleobase repertoire have hindered aptamer in application usage. To address these issues, new innovative methodologies, such as automation and single round SELEX, are being developed to improve the outcomes and rates in which aptamers are discovered.
自第一个适体分子被发现以来，已经过去了二十多年。从那时起，适体分子在科学领域备受关注。这种关注度的不断提高可归因于它们许多理想的特性，例如：1）它们具有结合多种分子的潜力；2）它们的可塑性；3）它们的生产成本低。这些特性使适体分子成为制药和生物传感器领域理想的研究平台。尽管适体有广泛的应用，但繁琐的程序、高资源消耗以及有限的核苷酸碱基库阻碍了适体的实际应用。为了解决这些问题，正在开发新的创新方法，如自动化和单轮指数富集的配体系统进化技术，以提高发现适体的效率和成功率。
Zotero 插件