Usai P, Cherchi M V, Boi M F, Cirillo R, Santa Cruz G, Solinas M P, Frau G, Balestrieri A
Recenti Prog Med. 1989 Feb;80(2):56-8.
The IgA antigliadin antibodies AGA title was detected in 37 patients with IDDM, mean age 32.59 +/- 14.71, where mean duration of disease was 8.76 +/- 9.62 years, and 29 patients with NIDDM, mean age 55.31 +/- 14.71, where disease lasted 11.5 +/- 5.55 years. A group of 51 normal pts. was employed as control. In IDDM group 2 cases on 37 showed high AGA title (case n. 1 and n. 2) but just the case n. 1 where IDDM lasted 16 years, showed an histologic picture of coeliac disease (partial villous atrophy), while in the case n. 2 where IDDM was at the onset, the histologic picture was normal. The increase of AGA title in the IDDM at the onset is rarely associated with coeliac disease, but it seems to be an aspecific response. Viceversa an increased AGA title is in IDDM for greater than 1 years often associated with coeliac disease. In NIDDM no high AGA title was found. The prevalence of coeliac disease in our patients with IDDM was 1:37 and we suggest that diabetics be screened routinely for antigliadin antibody.
在37例胰岛素依赖型糖尿病（IDDM）患者中检测到抗麦醇溶蛋白抗体（AGA）阳性，这些患者的平均年龄为32.59±14.71岁，平均病程为8.76±9.62年；在29例非胰岛素依赖型糖尿病（NIDDM）患者中也进行了检测，这些患者的平均年龄为55.31±14.71岁，病程持续11.5±5.55年。选取51名正常受试者作为对照。在IDDM组中，37例中有2例显示AGA阳性（病例1和病例2），但只有病例1（IDDM病程为16年）呈现乳糜泻的组织学表现（部分绒毛萎缩），而病例2处于IDDM发病初期，其组织学表现正常。IDDM发病初期AGA阳性很少与乳糜泻相关，但似乎是一种非特异性反应。反之，IDDM病程超过1年时AGA阳性增加常与乳糜泻相关。在NIDDM患者中未发现AGA阳性。我们的IDDM患者中乳糜泻的患病率为1:37，我们建议对糖尿病患者常规筛查抗麦醇溶蛋白抗体。
