青少年胰岛素依赖型糖尿病中的抗麦醇溶蛋白和抗网硬蛋白抗体

[Antigliadin and antireticulin antibodies in juvenile insulin-dependent diabetes mellitus].

作者信息

Barbera C, Fusco P, Gabetti L, Cerutti F, Sacchetti C

机构信息

Istituto di Discipline Pediatriche dell'Università di Torino, Italia.

出版信息

Pediatr Med Chir. 1988 Jan-Feb;10(1):33-7.

PMID:3375126

Abstract

A total of 203 patients with insulin-dependent diabetes mellitus (IDDM) were screened for coeliac disease (CD) by means of serum IgA and IgG antigliadin (AGA) (ELISA) and total anti reticulin antibody (ARA) IFL assay. As suggested by Savilhati, the combination of the IgA and IgG AGA test with IgA titration in serum (to find IgA deficient individuals) identifies almost 100% of CD patients. In this study ARA antibody assay was performed and two new suspect coeliac cases were found among IgA AGA negative children. Together the ARA and AGA tests give a 3% overall prevalence of CD in IDDM. The confirmation of CD must still be obtained with jejunal biopsy. Even high titres of AGA IgG are less specific for coeliac disease and in IDDM may identify those patients who are immunologically more hyperreactive.

摘要

采用血清IgA和IgG抗麦胶蛋白（AGA）（酶联免疫吸附测定）及总抗网硬蛋白抗体（ARA）间接荧光免疫测定法，对总共203例胰岛素依赖型糖尿病（IDDM）患者进行了乳糜泻（CD）筛查。正如萨维哈蒂所指出的，IgA和IgG AGA检测与血清IgA滴定法（以发现IgA缺乏个体）相结合，几乎可识别出100%的CD患者。在本研究中进行了ARA抗体检测，在IgA AGA阴性儿童中发现了2例新的疑似乳糜泻病例。ARA和AGA检测共同得出IDDM中CD的总体患病率为3%。CD的确诊仍必须通过空肠活检来获得。即使AGA IgG的高滴度对乳糜泻的特异性也较低，在IDDM中可能识别出免疫反应性更高的患者。