Paulson Spencer, Patel Charmi, Patel Hitendra
Department of Pathology, University of Arizona, Tucson, AZ 85724, USA.
Section of Hematology and Oncology, University of Arizona, Tucson, AZ 85724, USA.
Case Rep Pathol. 2016;2016:1738696. doi: 10.1155/2016/1738696. Epub 2016 Mar 24.
We report a rare association of hepatocellular carcinoma with familial adenomatous polyposis in a young patient and its clinical significance. A 28-year-old female with a past medical history of familial adenomatous polyposis (FAP) and subsequent colonic adenocarcinoma underwent total colectomy. She later presented with intermittent right upper quadrant pain and nausea of four months' duration. MRI of the abdomen revealed multiple liver lesions, the largest 8.5 cm in diameter, with radiologic features suggestive of hepatocellular carcinoma. A CT-guided liver biopsy demonstrated well-differentiated HCC which was confirmed by immunohistochemistry. In patients with a history of FAP, a heightened awareness of the possibility of concurrent or subsequent HCC is warranted.
我们报告了一名年轻患者中肝细胞癌与家族性腺瘤性息肉病的罕见关联及其临床意义。一名有家族性腺瘤性息肉病（FAP）病史并继发结肠腺癌的28岁女性接受了全结肠切除术。她后来出现持续四个月的间歇性右上腹疼痛和恶心。腹部MRI显示肝脏有多个病灶，最大直径8.5厘米，影像学特征提示肝细胞癌。CT引导下肝活检显示为高分化肝癌，免疫组化证实了这一诊断。对于有FAP病史的患者，有必要提高对同时发生或随后发生HCC可能性的认识。
