Klancic Teja, Woodward Lavinia, Hofmann Susanna M, Fisher Edward A
Institute for Diabetes and Regeneration Research, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
University of Oxford, Oxford, United Kingdom.
Mol Metab. 2016 Mar 18;5(5):321-327. doi: 10.1016/j.molmet.2016.03.001. eCollection 2016 May.
High density lipoproteins (HDLs) are thought to be atheroprotective and to reduce the risk of cardiovascular disease (CVD). Besides their antioxidant, antithrombotic, anti-inflammatory, anti-apoptotic properties in the vasculature, HDLs also improve glucose metabolism in skeletal muscle.
Herein, we review the functional role of HDLs to improve metabolic disorders, especially those involving insulin resistance and to induce regression of CVD with a particular focus on current pharmacological treatment options as well as lifestyle interventions, particularly exercise.
Functional properties of HDLs continue to be considered important mediators to reverse metabolic dysfunction and to regress atherosclerotic cardiovascular disease. Lifestyle changes are often recommended to reduce the risk of CVD, with exercise being one of the most important of these. Understanding how exercise improves HDL function will likely lead to new approaches to battle the expanding burden of obesity and the metabolic syndrome.
高密度脂蛋白（HDLs）被认为具有抗动脉粥样硬化作用，并能降低心血管疾病（CVD）风险。除了在血管系统中具有抗氧化、抗血栓形成、抗炎、抗凋亡特性外，HDLs还能改善骨骼肌中的葡萄糖代谢。
在此，我们综述HDLs在改善代谢紊乱，尤其是涉及胰岛素抵抗的代谢紊乱方面的功能作用，以及诱导心血管疾病消退的功能作用，特别关注当前的药物治疗选择以及生活方式干预，尤其是运动。
HDLs的功能特性仍然被认为是逆转代谢功能障碍和消退动脉粥样硬化性心血管疾病的重要介质。通常建议通过改变生活方式来降低心血管疾病风险，其中运动是最重要的方式之一。了解运动如何改善HDL功能可能会带来新方法，以应对肥胖和代谢综合征不断增加的负担。
