Bravi Francesca, Tavani Alessandra, Bosetti Cristina, Boffetta Paolo, La Vecchia Carlo
aDepartment of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri bThe Tisch Cancer Institute and Institute of Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA cDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Eur J Cancer Prev. 2017 Sep;26(5):368-377. doi: 10.1097/CEJ.0000000000000252.
An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. Thus, we carried out a systematic review and meta-analysis of prospective cohort studies that investigated the association between coffee consumption and the risk of HCC or CLD. We separately estimated the relative risk (RR) of the two conditions, for regular, low, and high consumption compared with no or occasional coffee consumption; we also calculated the summary RR for an increment of one cup of coffee per day. Twelve studies on HCC (3414 cases) and six studies on CLD (1463 cases) were identified. The summary RRs for HCC were 0.66 [95% confidence interval (CI): 0.55-0.78] for regular, 0.78 (95% CI: 0.66-0.91) for low, and 0.50 (95% CI: 0.43-0.58) for high coffee consumption, respectively. The summary RR for an increment of one cup per day was 0.85 (95% CI: 0.81-0.90). The summary RRs for CLD were 0.62 (95% CI: 0.47-0.82) for regular, 0.72 (95% CI: 0.59-0.88) for low, 0.35 (95% CI: 0.22-0.56) for high, and 0.74 (95% CI: 0.65-0.83) for an increment of one cup per day. The present meta-analysis provides a precise quantification of the inverse relation between coffee consumption and the risk of HCC, and adds evidence to the presence of an even stronger negative association with CLD.
据报道，咖啡饮用与肝细胞癌（HCC）和慢性肝病（CLD）风险之间存在负相关，但这种关联的程度仍不明确。因此，我们对调查咖啡消费与HCC或CLD风险之间关联的前瞻性队列研究进行了系统评价和荟萃分析。我们分别估计了经常、少量和大量饮用咖啡与不饮用或偶尔饮用咖啡相比，这两种疾病的相对风险（RR）；我们还计算了每天增加一杯咖啡的汇总RR。共纳入了12项关于HCC的研究（3414例病例）和6项关于CLD的研究（1463例病例）。HCC的汇总RR分别为：经常饮用咖啡为0.66 [95%置信区间（CI）：0.55 - 0.78]，少量饮用为0.78（95% CI：0.66 - 0.91），大量饮用为0.50（95% CI：0.43 - 0.58）。每天增加一杯咖啡的汇总RR为0.85（95% CI：0.81 - 0.90）。CLD的汇总RR分别为：经常饮用咖啡为0.62（95% CI：0.47 - 0.82），少量饮用为0.72（95% CI：0.59 - 0.88），大量饮用为0.35（95% CI：0.22 - 0.56），每天增加一杯咖啡为0.74（95% CI：0.65 - 0.83）。本荟萃分析精确量化了咖啡消费与HCC风险之间的负相关关系，并进一步证明了与CLD存在更强的负相关关系。
