循环白细胞介素-18：与有无心律紊乱患者的白细胞介素-8、白细胞介素-10及血管内皮生长因子血清水平的关联
Circulating interleukin-18: Association with IL-8, IL-10 and VEGF serum levels in patients with and without heart rhythm disorders.
作者信息
Vm Mitrokhin, Al Shim, Aa Aksyonov, As Zotov, Av Konev, Rs Ovchinnikov, Im Mladenov, Ga Kamkin
机构信息
Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
Federal Scientific Clinical Center for Specialized Types of Medical Assistance and Medical Technologies for the Federal Medical and Biological Agency, Orekhoviy Boulevard 28, Moscow 115682, Russia; Department of Fundamental and Applied Physiology, Russian National Research Medical University, Ostrovitjanova 1, Moscow 117997, Russia.
出版信息
Int J Cardiol. 2016 Jul 15;215:105-9. doi: 10.1016/j.ijcard.2016.04.002. Epub 2016 Apr 13.
BACKGROUND
An altered IL-18 pathway in patients with coronary artery disease has recently been described and this cytokine was shown to be of clinical and prognostic utility. Cardiomyocytes are a target of this cytokine which exerts inflammatory, hypertrophic and profibrotic activities.
OBJECTIVES
The aim of the study was to verify the ability of IL-18 to induce expression of other pro/anti-inflammatory cytokines and to analyse the relationship between these molecules in serum from patients with heart rhythm disorders and coronary artery disease.
METHODS
All patients in the study were divided into two groups: with heart rhythm disorders and without but with diagnosed coronary artery disease. Heart rhythm disorders included sinus node dysfunction, bradycardia and tachycardia.
RESULTS
The interrelationships among all tested clinical, biochemical and inflammatory parameters with a dependence on median IL-18 values were checked. From all tested parameters only cytokines IL-8, IL-10 and VEGF, were associated with the serum IL-18 levels.
CONCLUSION
IL-18, IL-8 and VEGF were identified as a factors involved in heart rhythm disorders and coronary artery disease patho-physiology and regarded as markers of prognostic significance and potential therapeutic targets. The demonstration of their in vivo relationship added new insights into the understanding of the interdependence of inflammatory pathways in patients with heart rhythm disorders or coronary artery disease.
背景
最近已有研究描述了冠状动脉疾病患者白细胞介素-18（IL-18）信号通路的改变，且该细胞因子具有临床及预后评估价值。心肌细胞是这种细胞因子的作用靶点，它具有促炎、致肥厚及促纤维化活性。
目的
本研究旨在验证IL-18诱导其他促炎/抗炎细胞因子表达的能力，并分析心律失常和冠状动脉疾病患者血清中这些分子之间的关系。
方法
本研究中的所有患者被分为两组：患有心律失常的患者和未患心律失常但确诊患有冠状动脉疾病的患者。心律失常包括窦房结功能障碍、心动过缓和心动过速。
结果
检查了所有测试的临床、生化和炎症参数之间的相互关系及其与IL-18中位数的相关性。在所有测试参数中，只有细胞因子IL-8、IL-10和血管内皮生长因子（VEGF）与血清IL-18水平相关。
结论
IL-18、IL-8和VEGF被确定为参与心律失常和冠状动脉疾病病理生理过程的因素，被视为具有预后意义的标志物和潜在的治疗靶点。它们体内关系的证明为理解心律失常或冠状动脉疾病患者炎症通路的相互依赖性提供了新的见解。
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