别嘌醇对利什曼病犬的不良泌尿影响。

Adverse urinary effects of allopurinol in dogs with leishmaniasis.

作者信息

Torres M, Pastor J, Roura X, Tabar M D, Espada Y, Font A, Balasch J, Planellas M

机构信息

Servei d'Urgències i Medecina Interna, Hospital Veterinari Balmes, Carrer Balmes 81, 08008 Barcelona, Spain.

Hospital Clínic Veterinari and Animal Medicine and Surgery Department, Faculty of Veterinary Medicine, Universitat Autònoma de Barcelona, Campus de la UAB, Plaza Cívica, 08193, Bellaterra, Spain.

出版信息

J Small Anim Pract. 2016 Jun;57(6):299-304. doi: 10.1111/jsap.12484. Epub 2016 Apr 26.

DOI:10.1111/jsap.12484

PMID:27112522

Abstract

OBJECTIVE

The objective of this study was to describe the adverse effects of allopurinol on the urinary system during treatment of canine leishmaniasis.

METHODS

Retrospective case series of 42 dogs that developed xanthinuria while receiving allopurinol treatment for leishmaniasis.

RESULTS

Of 320 dogs diagnosed with leishmaniasis, 42 (13%) developed adverse urinary effects. Thirteen (of 42) dogs (31%) developed xanthinuria, renal mineralisation and urolithiasis; 11 (26·2%) showed xanthinuria with renal mineralisation; 9 (21·4%) had xanthinuria with urolithiasis and 9 (21·4%) developed xanthinuria alone. Urinary clinical signs developed in 19 dogs (45·2%).

CLINICAL SIGNIFICANCE

This study demonstrates that urolithiasis and renal mineralisation can occur in dogs receiving allopurinol therapy. Dogs receiving therapy should be monitored for the development of urinary adverse effects from the beginning of treatment.

摘要

目的

本研究的目的是描述别嘌醇在犬利什曼病治疗期间对泌尿系统的不良反应。

方法

对42只在接受别嘌醇治疗利什曼病期间出现黄嘌呤尿的犬进行回顾性病例系列研究。

结果

在320只被诊断为利什曼病的犬中，42只（13%）出现了泌尿系统不良反应。42只犬中有13只（31%）出现了黄嘌呤尿、肾矿化和尿石症；11只（26.2%）表现为伴有肾矿化的黄嘌呤尿；9只（21.4%）有伴有尿石症的黄嘌呤尿，9只（21.4%）仅出现黄嘌呤尿。19只犬（45.2%）出现了泌尿系统临床症状。