Kaempfle Melanie, Bergmann Michèle, Koelle Petra, Hartmann Katrin
LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, 80539 Munich, Germany.
Animals (Basel). 2023 Sep 29;13(19):3060. doi: 10.3390/ani13193060.
Reducing the alimentary purine intake contributes to the prevention of purine (especially xanthine) urolith formation, a common adverse effect of allopurinol treatment in dogs with infections. Analyses of the purine content are not required in order to advertise a diet as low in purine. Due to different analytical methods, data provided on purine content are barely comparable. The aim of this study was to investigate the total purine content of 12 different dog diets. For this, the purine bases adenine, guanine, xanthine, and hypoxanthine were determined by standardised high performance liquid chromatography in commercially available urinary diets (n = 4), kidney diets (n = 2), low protein diets (n = 3), 1 vegan diet, 1 regular diet for healthy adult dogs, and 1 homemade low purine diet. Total purine amounts ranged between 10.2 and 90.9 mg/100 g of dry matter. The daily purine intake calculated for a 20 kg standard dog with the analysed diets ranged between 21.9 and 174.7 mg. The lowest daily purine intakes were achieved by 2 urinary urate diets, followed by the homemade diet. Differences in the purine content of commercially available diets need to be considered. Awareness has to be raised when selecting diets for dogs with infections during allopurinol treatment in order to minimise the risk of urolith formation.
减少食物中的嘌呤摄入量有助于预防嘌呤（尤其是黄嘌呤）尿路结石的形成，这是别嘌醇治疗感染犬时常见的不良反应。宣传一种饮食为低嘌呤饮食并不需要对嘌呤含量进行分析。由于分析方法不同，所提供的嘌呤含量数据几乎无法比较。本研究的目的是调查12种不同犬粮的总嘌呤含量。为此，通过标准化高效液相色谱法测定了市售泌尿处方粮（n = 4）、肾脏处方粮（n = 2）、低蛋白粮（n = 3）、1种纯素粮、1种健康成年犬常规粮和1种自制低嘌呤粮中的嘌呤碱腺嘌呤、鸟嘌呤、黄嘌呤和次黄嘌呤。总嘌呤含量在10.2至90.9毫克/100克干物质之间。用分析的犬粮计算20千克标准犬的每日嘌呤摄入量在21.9至174.7毫克之间。2种泌尿尿酸处方粮的每日嘌呤摄入量最低，其次是自制粮。需要考虑市售犬粮中嘌呤含量的差异。在为接受别嘌醇治疗的感染犬选择犬粮时，必须提高认识，以尽量降低尿路结石形成的风险。
