Budach V, Bamberg M, Sack H, Rauhut F, Rassow J
Department of Radiooncology, University of Essen, F.R.G.
Strahlenther Onkol. 1989 Apr;165(4):315-9.
Between 1980 and 1986 ten patients (two males, eight females, median age: 35 years) with spongioblastomas and ependymomas grade I of the spinal cord were treated with fast neutrons from the d(14) + Be reaction after incomplete tumour surgery. Eight patients received three weekly fractions of 0.7 to 1.33 Gy and two patients four weekly fractions of 0.8 Gy to total doses of 7.4 to 10.4 Gy. Two complete and six partial remissions of ataxia and motor disturbances were observed. Bladder dysfunctions in five patients cleared up partially in three cases. In two patients the symptomatology remained unchanged. After a follow-up of eight to 88 months two initially complete and two out of six partial remission were maintained. No severe late effects of the skin have been determined. In summary it is concluded that for incompletely resected "pencil"-gliomas fast neutron therapy seems to be a feasible treatment modality.
1980年至1986年间，10例脊髓I级海绵状细胞瘤和室管膜瘤患者（2例男性，8例女性，中位年龄：35岁）在肿瘤手术未完全切除后接受了d（14）+Be反应产生的快中子治疗。8例患者每周接受3次剂量为0.7至1.33 Gy的照射，2例患者每周接受4次剂量为0.8 Gy的照射，总剂量为7.4至10.4 Gy。观察到2例完全缓解，6例共济失调和运动障碍部分缓解。5例患者的膀胱功能障碍在3例中部分恢复。2例患者症状未改变。随访8至88个月后，2例最初完全缓解的患者和6例部分缓解患者中的2例仍保持缓解状态。未发现皮肤有严重的晚期效应。总之，得出结论：对于未完全切除的“铅笔样”胶质瘤，快中子治疗似乎是一种可行的治疗方式。
