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1
The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.
EMBO Rep. 2016 May;17(5):638-47. doi: 10.15252/embr.201540500. Epub 2016 Apr 9.
2
Remarkable Evolutionary Conservation of Antiobesity ADIPOSE/WDTC1 Homologs in Animals and Plants.
Genetics. 2017 Sep;207(1):153-162. doi: 10.1534/genetics.116.198382. Epub 2017 Jun 29.
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SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes.
FEBS J. 2017 Nov;284(21):3619-3636. doi: 10.1111/febs.14259. Epub 2017 Oct 10.
6
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Nature. 2006 Oct 5;443(7111):590-3. doi: 10.1038/nature05175.
7
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Nat Cell Biol. 2006 Nov;8(11):1277-83. doi: 10.1038/ncb1490. Epub 2006 Oct 15.
10
The CRL4 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
EMBO J. 2021 Nov 15;40(22):e108008. doi: 10.15252/embj.2021108008. Epub 2021 Sep 30.

引用本文的文献

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CSN-CRL Complexes: New Regulators of Adipogenesis.
Biomolecules. 2025 Mar 5;15(3):372. doi: 10.3390/biom15030372.
2
Identifying shared diagnostic genes and mechanisms in vascular dementia and Alzheimer's disease via bioinformatics and machine learning.
J Alzheimers Dis Rep. 2024 Nov 24;8(1):1558-1572. doi: 10.1177/25424823241289804. eCollection 2024.
3
Evaluation of large language models for discovery of gene set function.
Nat Methods. 2025 Jan;22(1):82-91. doi: 10.1038/s41592-024-02525-x. Epub 2024 Nov 28.
4
Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation.
Cells. 2024 Oct 5;13(19):1654. doi: 10.3390/cells13191654.
5
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma.
Mol Cancer. 2023 Nov 18;22(1):184. doi: 10.1186/s12943-023-01871-2.
6
SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway.
Nat Commun. 2023 Nov 17;14(1):7441. doi: 10.1038/s41467-023-43283-2.
7
A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.
Development. 2023 Oct 15;150(20). doi: 10.1242/dev.201769. Epub 2023 Oct 16.
9
TRiC/CCT chaperonin is required for the folding and inhibitory effect of WDTC1 on adipogenesis.
Front Cell Dev Biol. 2023 Aug 24;11:1225628. doi: 10.3389/fcell.2023.1225628. eCollection 2023.
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The Effects of on Inducing Differentiation in Ovine Preadipocytes via Oar-miR-432.
Int J Mol Sci. 2023 Jul 17;24(14):11567. doi: 10.3390/ijms241411567.

本文引用的文献

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Adipose induces myoblast differentiation and mediates TNFα-regulated myogenesis.
Biochim Biophys Acta. 2014 Nov;1839(11):1183-95. doi: 10.1016/j.bbagrm.2014.07.018. Epub 2014 Aug 1.
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A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity.
Cell Metab. 2014 Feb 4;19(2):331-43. doi: 10.1016/j.cmet.2013.12.004.
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Adipose tissue expression of adipose (WDTC1) gene is associated with lower fat mass and enhanced insulin sensitivity in humans.
Obesity (Silver Spring). 2013 Nov;21(11):2244-8. doi: 10.1002/oby.20371. Epub 2013 Jun 11.
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CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
Cancer Cell. 2012 Dec 11;22(6):781-95. doi: 10.1016/j.ccr.2012.10.024.
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The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Cell. 2011 Nov 23;147(5):1024-39. doi: 10.1016/j.cell.2011.10.035.
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A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.
J Biol Chem. 2011 Sep 30;286(39):34325-34. doi: 10.1074/jbc.M111.277798. Epub 2011 Aug 10.
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Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication.
J Cell Biol. 2010 Nov 29;191(5):953-66. doi: 10.1083/jcb.201006043. Epub 2010 Nov 22.
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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Nature. 2010 Jul 22;466(7305):451-6. doi: 10.1038/nature09291.
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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.
Nat Struct Mol Biol. 2010 Jan;17(1):105-11. doi: 10.1038/nsmb.1719. Epub 2009 Dec 6.

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