复制时间与转录调控：因果之外——第三部分
Replication timing and transcriptional control: beyond cause and effect-part III.
作者信息
Rivera-Mulia Juan Carlos, Gilbert David M
机构信息
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; Center for Genomics and Personalized Medicine, Florida State University, Tallahassee, FL, USA.
出版信息
Curr Opin Cell Biol. 2016 Jun;40:168-178. doi: 10.1016/j.ceb.2016.03.022. Epub 2016 Apr 23.
Abstract
DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
摘要
DNA复制对于遗传信息的准确传递至关重要，并且与染色体的结构和功能密切相关。基因组复制按照一种特定的时间顺序发生，即复制时间（RT）程序，该程序在细胞周期和发育过程中受到调控，其离散单元被称为复制结构域（RDs）。RDs对应于拓扑相关结构域（TADs），并在细胞核中进行时空分隔。虽然实验工具的改进已开始揭示因果关系的端倪，但也揭示了复杂的上下文依赖关系，这些关系挑战了长期以来公认的RT与染色质组织和基因调控之间的相关性。特别是，在发育过程中切换RT的RDs/TADs有着不同的节奏。
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