Robinson S L, Chambers E S, Fletcher G, Wallis G A
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.
Nutrition and Dietetic Research Group, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland.
Int J Sports Med. 2016 Jul;37(8):607-13. doi: 10.1055/s-0042-100291. Epub 2016 Apr 26.
The maximal capacity to oxidize fat during exercise (MFO) is associated with 24-h fat balance and insulin sensitivity. Understanding factors that influence MFO could have implications for metabolic health. We investigated relationships between selected plasma metabolites, hormones and overnight-fasted resting fat oxidation rates (Resting), with MFO. Resting fat oxidation and MFO was measured in 57 men with blood collected at rest and during exercise. Plasma glycerol (R=0.39, P=0.033), non-esterified fatty acids (NEFA: R=0.27, P=0.030) and insulin (R=- 0.36, P=0.007) measured at MFO correlated with MFO; only glycerol remained correlated when controlled for resting concentrations (R=0.36, P=0.008). The change in glycerol from rest to MFO correlated with exercise-induced fat oxidation (R=0.32, P=0.012). V˙O 2max correlated with resting fat oxidation (R=0.44, P=0.001) and MFO (R=0.52, P<0.001). Resting fat oxidation correlated with MFO (R=0.55, P<0.001); this remained when controlled for V˙O 2max (R=0.41, P=0.001). This study reports weak-to-moderate, albeit significant, relationships between plasma lipolytic markers, insulin and resting overnight-fasted fat oxidation with MFO and shows the plasma glycerol response to uniquely reflect exercise-induced fat oxidation. V˙O 2max correlates with fat oxidation but the relationship can be dissociated. Interventions to increase fat oxidation for optimal metabolic health would benefit from, but are not reliant on, increases in V˙O 2max.
运动期间氧化脂肪的最大能力（MFO）与24小时脂肪平衡及胰岛素敏感性相关。了解影响MFO的因素可能对代谢健康有重要意义。我们研究了选定的血浆代谢物、激素与过夜禁食静息脂肪氧化率（静息状态）和MFO之间的关系。在57名男性中测量了静息脂肪氧化和MFO，并在静息和运动期间采集血液。在MFO时测量的血浆甘油（R = 0.39，P = 0.033）、非酯化脂肪酸（NEFA：R = 0.27，P = 0.030）和胰岛素（R = -0.36，P = 0.007）与MFO相关；当控制静息浓度时，只有甘油仍具有相关性（R = 0.36，P = 0.008）。从静息到MFO时甘油的变化与运动诱导的脂肪氧化相关（R = 0.32，P = 0.012）。最大摄氧量（V˙O₂max）与静息脂肪氧化（R = 0.44，P = 0.001）和MFO（R = 0.52，P < 0.001）相关。静息脂肪氧化与MFO相关（R = 0.55，P < 0.001）；在控制V˙O₂max后该相关性仍然存在（R = 0.41，P = 0.001）。本研究报告了血浆脂解标志物、胰岛素以及过夜禁食静息脂肪氧化与MFO之间存在弱至中等程度但显著的关系，并表明血浆甘油反应能独特地反映运动诱导的脂肪氧化。V˙O₂max与脂肪氧化相关，但这种关系可以分离。为实现最佳代谢健康而增加脂肪氧化的干预措施将受益于V˙O₂max的增加，但并不依赖于此。
