Xu Xijin, Tang Qian, Xia Haiyue, Zhang Yuling, Li Weiqiu, Huo Xia
Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515041, Guangdong, China.
Department of Cell Biology and Genetics, Shantou University Medical College, Shantou 515041, Guangdong, China.
Sci Rep. 2016 Apr 27;6:25005. doi: 10.1038/srep25005.
Chaotic time series prediction based on nonlinear systems showed a superior performance in prediction field. We studied prenatal exposure to polychlorinated biphenyls (PCBs) by chaotic time series prediction using the least squares self-exciting threshold autoregressive (SEATR) model in umbilical cord blood in an electronic waste (e-waste) contaminated area. The specific prediction steps basing on the proposal methods for prenatal PCB exposure were put forward, and the proposed scheme's validity was further verified by numerical simulation experiments. Experiment results show: 1) seven kinds of PCB congeners negatively correlate with five different indices for birth status: newborn weight, height, gestational age, Apgar score and anogenital distance; 2) prenatal PCB exposed group at greater risks compared to the reference group; 3) PCBs increasingly accumulated with time in newborns; and 4) the possibility of newborns suffering from related diseases in the future was greater. The desirable numerical simulation experiments results demonstrated the feasibility of applying mathematical model in the environmental toxicology field.
基于非线性系统的混沌时间序列预测在预测领域表现出卓越性能。我们在一个电子垃圾(电子废弃物)污染地区,运用最小二乘自激阈值自回归(SEATR)模型,通过混沌时间序列预测研究了脐带血中多氯联苯(PCBs)的产前暴露情况。提出了基于所提方法的产前多氯联苯暴露的具体预测步骤,并通过数值模拟实验进一步验证了所提方案的有效性。实验结果表明:1)七种多氯联苯同系物与出生状况的五个不同指标呈负相关,这五个指标分别为新生儿体重、身高、孕周、阿氏评分和肛殖距;2)与参照组相比,产前多氯联苯暴露组面临更大风险;3)多氯联苯在新生儿体内随时间不断累积;4)新生儿未来患相关疾病的可能性更大。理想的数值模拟实验结果证明了将数学模型应用于环境毒理学领域的可行性。