Huang Chongbiao, Tian Ye, Cui Yan, Xu Jie, Xin Liang, Yang Xueling, Qi Daliang
Department of Senior Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Department of Interventional Treatment, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Zhongguo Fei Ai Za Zhi. 2016 Apr 20;19(4):230-5. doi: 10.3779/j.issn.1009-3419.2016.04.09.
Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the field of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of an α chain P35 and a β chain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inflammatory diseases and autoimmune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.
白细胞介素（IL）-35是白细胞介素-12超家族的新成员。自2007年首次报道以来，IL-35迅速成为免疫学领域的研究热点。与其他白细胞介素-12超家族成员一样，IL-35是一种异二聚体，由α链P35和β链爱泼斯坦-巴尔病毒诱导基因3（EBI3）组成。最近的研究工作揭示了IL-35的两个不同作用。首先，IL-35在某些炎症性疾病和自身免疫性疾病中高表达，并在发病机制中发挥重要作用。其次，IL-35在某些癌症中呈阳性表达，并在肿瘤进展过程中发挥一些作用。在此我们阐述了IL-35的结构和信号传导。我们综述了IL-35在促进肿瘤进展中的作用。
