Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Students Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
J Cell Biochem. 2020 Mar;121(3):2064-2076. doi: 10.1002/jcb.29441. Epub 2019 Oct 21.
Interleukin 35 (IL-35), a cytokine mainly produced by regulatory T cells (Treg cells), is composed of an Epstein-Barr virus-induced gene 3 β-chain and an IL-12 p35 α-chain. IL-35 causes tumorigenicity in cancer, protects cancer cells against apoptosis, and facilitates cancer progression. However, a few reports have referred to its contradictory roles in cancer prevention. Therefore, the exact purpose of this cytokine in cancer development has become a fundamental question that needs to be answered. In this review, we explain the structure of IL-35 and its receptors and their different signaling pathways. Finally, the function of IL-35 in some cancers and the possible application of this cytokine in approaches for cancer therapy have been discussed.
白细胞介素 35（IL-35），一种主要由调节性 T 细胞（Treg 细胞）产生的细胞因子，由 Epstein-Barr 病毒诱导基因 3β 链和白细胞介素 12 p35α 链组成。IL-35 在癌症中具有致瘤性，可保护癌细胞免于凋亡，并促进癌症进展。然而，有少数报道提到了它在癌症预防中的矛盾作用。因此，这种细胞因子在癌症发展中的确切作用成为一个需要回答的基本问题。在这篇综述中，我们解释了 IL-35 的结构及其受体，以及它们不同的信号通路。最后，讨论了 IL-35 在一些癌症中的作用，以及该细胞因子在癌症治疗方法中的可能应用。
